Evidence map›Paper›PMID 41178527›Full record

ArticleJournal of neurochemistry2025

BH4 Oxidation-Derived H

Milad Mohammadi, Maike Siobal, Jörg Isensee, Philipp N Ostermann, Tim Hucho

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of neurochemistry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. BH4 Oxidation-Derived HJournal of neurochemistry · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Milad MohammadiTranslational Pain Research, Department of Anesthesiology and Intensive Care Medicine, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany.
Maike SiobalTranslational Pain Research, Department of Anesthesiology and Intensive Care Medicine, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany.
Jörg IsenseeTranslational Pain Research, Department of Anesthesiology and Intensive Care Medicine, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany.
Philipp N OstermannTranslational Pain Research, Department of Anesthesiology and Intensive Care Medicine, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany.ORCID 0000-0002-4419-6119
Tim HuchoTranslational Pain Research, Department of Anesthesiology and Intensive Care Medicine, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany.ORCID 0000-0002-4147-9308

Funding

Deutsche Forschungsgemeinschaft 516750869European Union EFRE-08009700LeitmarktAgentur.NRW LS-1-2-023a
6 · The paper itself

Abstract

Elevated Tetrahydrobiopterin (BH4) levels are linked to various pain conditions. Pharmacological or genetic reduction of BH4 levels has analgesic effects in rodent models of neuropathic and inflammatory pain, but also affects neurological and cardiovascular functions. Little is known about the downstream mechanisms of BH4 that could be targeted to attenuate BH4-induced pain hypersensitivity without lowering BH4 levels. In this study, we exposed ex vivo-cultured rat dorsal root ganglion (DRG) neurons to BH4 and analyzed the activity of the sensory neuron-sensitizing kinase ERK1/2 via high-content imaging. We show that BH4 exposure leads to increased pERK1/2 levels in a dose- and time-dependent manner. Interestingly, we found that H

Indexed as

BiopterinsGanglia, SpinalHydrogen PeroxideMAP Kinase Signaling SystemNeuronsAnimalsCells, CulturedMaleOxidation-ReductionRatsRats, Sprague-DawleyBiopterinsHydrogen PeroxidesapropterinBH4B‐Rafchronic paindorsal root ganglion neuronERK1/2 signalingMEKnociceptorreactive oxygen speciestetrahydrobiopterin

Identifiers

PMID41178527
PMCPMC12580945

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.