Evidence map›Paper›PMID 41178491›Full record

ArticleBritish journal of haematology2026

Pharmacokinetic and pharmacodynamic evaluation of alternative pomalidomide dosing regimens in the treatment of multiple myeloma.

M R Seefat, D G J Cucchi, L van Boven, N Durdu-Rayman, K Groen, M-D Levin, K de Heer, B de Valk, R Wester, E van der Spek and 12 more

Abstract read
In one paragraph

Article in British journal of haematology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

22 authors.

M R SeefatDepartment of Haematology, Amsterdam UMC, Cancer Centre Amsterdam, Amsterdam, The Netherlands.ORCID https://orcid.org/0000-0002-0824-0354
D G J CucchiDepartment of Haematology, Amsterdam UMC, Cancer Centre Amsterdam, Amsterdam, The Netherlands.
L van BovenDepartment of Clinical Pharmacology and Pharmacy, Amsterdam UMC, Amsterdam, the Netherlands.
N Durdu-RaymanDepartment of Internal Medicine, Franciscus Gasthuis & Vlietland, Rotterdam, The Netherlands.
K GroenDepartment of Haematology, Amsterdam UMC, Cancer Centre Amsterdam, Amsterdam, The Netherlands.
M-D LevinDepartment of Internal Medicine, Albert Schweitzer Ziekenhuis, Dordrecht, The Netherlands.
K de HeerDepartment of Haematology, Amsterdam UMC, Cancer Centre Amsterdam, Amsterdam, The Netherlands.
B de ValkDepartment of Haematology and Medical Oncology, Spaarne Gasthuis, Hoofddorp, The Netherlands.
R WesterDepartment of Haematology, Erasmus MC Cancer Institute, University Medical Centre Rotterdam, Rotterdam, The Netherlands.
E van der SpekDepartment of Internal Medicine, Rijnstate Hospital, Arnhem, The Netherlands.
R RentenaarDepartment of Haematology, Amsterdam UMC, Cancer Centre Amsterdam, Amsterdam, The Netherlands.
C L B M KorstDepartment of Haematology, Amsterdam UMC, Cancer Centre Amsterdam, Amsterdam, The Netherlands.ORCID https://orcid.org/0009-0005-0191-4343
M QuikDepartment of Haematology, Amsterdam UMC, Cancer Centre Amsterdam, Amsterdam, The Netherlands.
C A O'NeillDepartment of Haematology, Amsterdam UMC, Cancer Centre Amsterdam, Amsterdam, The Netherlands.
P TzortziDepartment of Haematology, Amsterdam UMC, Cancer Centre Amsterdam, Amsterdam, The Netherlands.
F SmitsDepartment of Haematology, Amsterdam UMC, Cancer Centre Amsterdam, Amsterdam, The Netherlands.
R MathotDepartment of Internal Medicine, Franciscus Gasthuis & Vlietland, Rotterdam, The Netherlands.ORCID https://orcid.org/0000-0001-8401-0879
M R Heerma van VossDepartment of Haematology, Amsterdam UMC, Cancer Centre Amsterdam, Amsterdam, The Netherlands.
N W C J van de DonkDepartment of Haematology, Amsterdam UMC, Cancer Centre Amsterdam, Amsterdam, The Netherlands.
T MutisDepartment of Haematology, Amsterdam UMC, Cancer Centre Amsterdam, Amsterdam, The Netherlands.ORCID https://orcid.org/0000-0002-5557-7187
I H BartelinkDepartment of Internal Medicine, Franciscus Gasthuis & Vlietland, Rotterdam, The Netherlands.
S ZweegmanDepartment of Haematology, Amsterdam UMC, Cancer Centre Amsterdam, Amsterdam, The Netherlands.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Standard pomalidomide dosing (4 mg/day for 21 of 28 days) achieved the most robust pharmacokinetic (PK) and pharmacodynamic (PD) effects. Daily dosing with pomalidomide 2 mg is a safe alternative for patients at risk of toxicity; alternate-day dosing was less effective.

Indexed as

Multiple MyelomaThalidomideAgedDrug Administration ScheduleFemaleHumansMaleMiddle AgedpomalidomideThalidomideDosingMultiple myelomaPharmacodynamicPharmacokineticPomalidomide

Identifiers

PMID41178491
PMCPMC12819103

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.