Evidence map›Paper›PMID 41178486›Full record

ArticleActa otorhinolaryngologica Italica : organo ufficiale della Societa italiana di otorinolaringologia e chirurgia cervico-facciale2025

Optimising care for chronic rhinosinusitis with nasal polyps and asthma in multimorbid patients: a multidisciplinary Delphi consensus.

Eugenio De Corso, Adriano Vaghi, Marco Corbò, Carlotta Pipolo, Alessandra Vultaggio, Andrea Matucci, Elena Cantone, Gianenrico Senna, Marco Caminati, Frank Rikki Canevari and 36 more

Abstract readConsensus Statement
PubMed Full text at PMC Publisher
In one paragraph

Article in Acta otorhinolaryngologica Italica : organo ufficiale della Societa italiana di otorinolaringologia e chirurgia cervico-facciale, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Switching to dupilumab from other biologic therapies in chronic rhinosinusitis with nasal polyps (CRSWNP): a comparison with biologic-naïve patients.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2026
    Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

46 authors.

Eugenio De CorsoOtorhinolaryngology Unit, Head and Neck Department, Fondazione Policlinico Universitario A. Gemelli Hospital IRCCS, Rome, Italy.
Adriano VaghiDepartment of Medicine and Rehabilitation, Guido Salvini Hospital-ASST Rhodense, Garbagnate Milanese (MI), Italy.
Marco CorbòOtorhinolaryngology Unit, Head and Neck Department, Fondazione Policlinico Universitario A. Gemelli Hospital IRCCS, Rome, Italy.
Carlotta PipoloOtorhinolaryngology Unit, Head and Neck Department, ASST Santi Paolo e Carlo Hospital, Milan, Italy.
Alessandra VultaggioDepartment of Experimental and Clinical Medicine, University of Florence, Florence, Italy; Immunoallergology Unit, Careggi University Hospital, Florence, Italy.
Andrea MatucciDepartment of Experimental and Clinical Medicine, University of Florence, Florence, Italy; Immunoallergology Unit, Careggi University Hospital, Florence, Italy.
Elena CantoneNeurosciences, Reproductive and Odontostomatologic Sciences, Unit of Ear, Nose and Throat, Federico II University, Naples, Italy.
Gianenrico SennaAsthma Center and Allergy Unit, University of Verona and General Hospital, Verona, Italy.
Marco CaminatiAsthma Center and Allergy Unit, University of Verona and General Hospital, Verona, Italy.
Frank Rikki CanevariDepartment 1 DISC, Otorhinolaryngology Unit, IRCCS Policlinico San Martino, University of Genoa, Genoa, Italy.
Carlo LombardiDepartmental Unit of Allergology, Clinical Immunology & Pneumology, Istituto Ospedaliero Fondazione Poliambulanza, Brescia, Italy.
Aikaterini DetorakiDepartment of Internal Medicine and Clinical Complexities, Azienda Ospedaliera Universitaria Federico II, Naples, Italy.
Giorgio Walter CanonicaPersonalized Medicine, Asthma and Allergy, Humanitas Clinical and Research Center, IRCCS, Rozzano, Italy.
Jan Walter SchroederAllergy and Clinical Immunology, ASST Grande Ospedale Metropolitano Niguarda, Milan, Italy.
Maria D'AmatoUOSD Malattie Respiratorie "Federico II", Ospedale Monaldi, AO Dei Colli, Naples, Italy.
Maria Angiola CrivellaroAllergy Service, Department of Medicine and Public Health, University of Padua, Padua, Italy.
Matteo GelardiUnit of Otolaryngology, University of Foggia, Foggia, Italy.
Francesco Antonio SalzanoUnit of Otolaryngology, University Hospital "San Giovanni di Dio e Ruggi, D'Aragona", Salerno, Italy.
Davide MattavelliUnit of Otorhinolaryngology-Head and Neck Surgery, ASST Spedali Civili Brescia, Department of Medical and Surgical Specialties, Radiological Sciences and Public Health, University of Brescia, Brescia, Italy.
Vittorio RampinelliUnit of Otorhinolaryngology-Head and Neck Surgery, ASST Spedali Civili Brescia, Department of Medical and Surgical Specialties, Radiological Sciences and Public Health, University of Brescia, Brescia, Italy.
Alberto MacchiENT Clinic ASST Settelaghi, Head and Neck Research Foresic Center, Insubria University, Varese, Italy.
Ernesto PasquiniENT Unit, Azienda USL di Bologna, Ospedale Bellaria, Bologna, Italy.
Manuele CasaleIntegrated Therapies in Otolaryngology, Campus Bio-Medico University, Rome, Italy.
Stefania GalloENT Clinic ASST Settelaghi, Head and Neck Research Foresic Center, Insubria University, Varese, Italy.
Girolamo PelaiaDepartment of Health Sciences, University "Magna Graecia" of Catanzaro, Catanzaro, Italy.
Claudia CrimiDepartment of Clinical and Experimental Medicine, University of Catania, Catania, Italy; Policlinico "G. Rodolico - San Marco" University Hospital, Catania, Italy.
Giovanna Elisiana CarpagnanoInstitute of Respiratory Diseases, Department DIBRAIN, University of Medicine, Bari, Italy.
Enrico HefflerDepartment of Biomedical Sciences, Humanitas University, Pieve Emanuele, Milan, Italy; Personalized Medicine Asthma and Allergy, IRCCS Humanitas Research Hospital, Rozzano (MI), Italy
Eustachio NettisRegional Reference Center for Allergic and Immunological Diseases, Department of Precision and Regenerative Medicine and Ionian Area, University of Bari Aldo Moro, Bari, Italy.
Maria Beatrice BilòDISCLIMO, Università Politecnica delle Marche, Italy; Allergy Unit, Department of Internal Medicine, University Hospital AOU Delle Marche, Ancona, Italy.
Veronica SecciaOtolaryngology, Audiology, and Phoniatric Operative Unit, Department of Surgical, Medical, Molecular Pathology, and Critical Care Medicine, Pisa University Hospital, Pisa, Italy.
Giancarlo OttavianoDepartment of Neurosciences, Section of Otolaryngology, University of Padua, Padua, Italy.
Claudio MichelettoPulmonary Unit, Integrated University Hospital of Verona, Verona, Italy.
Stefano Del GiaccoDepartment of Medical Sciences and Public Health, University of Cagliari, Monserrato, Italy.
Cristiano CarusoUOSD Allergology and Clinical Immunology, Department of Abdominal and Endocrine-Metabolic Medical and Surgical Sciences, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy.
Diego BagnascoSection of Respiratory Diseases and Allergology - Department of Internal Medicine (DIMI), University of Genoa, IRCCS - Ospedale Policlinico San Martino, Genoa, Italy.
Matteo BoniniDepartment of Public Health and Infectious Diseases, Sapienza University, Rome, Italy.
Francesco MenzellaPulmonology Unit, S. Valentino Hospital, Montebelluna (TV), AULSS2 Marca Trevigiana, Italy.
Giulio Cesare PassaliUnit of Otorhinolaryngology and Head-Neck Surgery, "A. Gemelli" Hospital Foundation IRCCS, Rome, Italy.
Giandomenico MaggioreDepartment of Otolaryngology, AOU Careggi, Florence, Italy.
Fabiano Di MarcoRespiratory Medicine Unit, ASST Papa Giovanni XXIII, Bergamo; Health Science Department, University of Milan.
Francesco Maria PassaliENT Department, University Tor Vergata, Rome, Italy.
Loreta Di MicheleDepartment of Pulmonary Interstitial Diseases, San Camillo Forlanini Hospital, Rome, Italy.
Giampietro RicciDepartment of Medicine and Surgery, Section of Otorhinolaryngology, University of Perugia, Perugia, Italy.
Jacopo GalliOtorhinolaryngology Unit, Head and Neck Department, Fondazione Policlinico Universitario A. Gemelli Hospital IRCCS, Rome, Italy.
Fabio PagellaDepartment of Clinical, Surgical, Diagnostic and Pediatric Sciences, University of Pavia, Pavia, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objective: Chronic rhinosinusitis with nasal polyps (CRSwNP) and asthma often coexist and share common underlying pathophysiological mechanisms. This study addresses challenges in the diagnosis and treatment of multimorbid patients with CRSwNP and asthma providing new insights for their management. Methods: Using a modified Delphi method, a scientific board of 40 Italian clinicians (pulmonologists, allergists/clinical immunologists, and ear, nose, and throat specialists) developed consensus statements regarding the multimorbid patient with severe CRSwNP and asthma and including the disease burden, assessment, treatment and multidisciplinary management of multimorbid patients. Results: All statements reached consensus. Experts acknowledged the substantial disease burden, the key pathophysiological role of type 2 inflammation in multimorbid patients and the need for multidisciplinary care. The use of biologics represents a highly effective therapeutic opportunity for patients with comorbidities, optimising overall outcomes. Integrated care pathways and regular multidisciplinary re-assessment were deemed essential for treatment decisions and improved care in multimorbid patients. Conclusions: This consensus highlights the value of a multidisciplinary approach for multimorbid CRSwNP and asthma patients, advocating for endotype-driven therapies and standardised pathways in clinical practice.

Indexed as

AsthmaNasal PolypsRhinitisSinusitisChronic DiseaseDelphi TechniqueHumansMultimorbidityRhinosinusitisasthmabiologic therapychronic rhinosinusitiscomorbiditiesnasal polypsprecision medicine

Identifiers

PMID41178486
PMCPMC12581958

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.