Evidence map›Paper›PMID 41178462›Full record

ArticleMolecular oncology2026

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway.

Arnatchai Maiuthed, Kerstin Huebner, Katharina Erlenbach-Wuensch, Chuanpit Hampel, Daniela Thalheim, Adriana Vial-Roehe, Bodee Nutho, Susanne Merkel, Arndt Hartmann, Pithi Chanvorachote and 1 more

Abstract read
In one paragraph

Article in Molecular oncology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Arnatchai MaiuthedDepartment of Pharmacology, Faculty of Pharmacy, Mahidol University, Bangkok, Thailand.
Kerstin HuebnerDepartment of Experimental Tumor Pathology, Universitätsklinikum, Friedrich-Alexander Universität Erlangen-Nürnberg (FAU), Erlangen, Germany.
Katharina Erlenbach-WuenschInstitute of Pathology, Universitätsklinikum, Friedrich-Alexander Universität Erlangen-Nürnberg (FAU), Erlangen, Germany.
Chuanpit HampelDepartment of Experimental Tumor Pathology, Universitätsklinikum, Friedrich-Alexander Universität Erlangen-Nürnberg (FAU), Erlangen, Germany.
Daniela ThalheimDepartment of Experimental Tumor Pathology, Universitätsklinikum, Friedrich-Alexander Universität Erlangen-Nürnberg (FAU), Erlangen, Germany.
Adriana Vial-RoeheDepartment of Pathology, Federal University of Health Sciences of Porto Alegre (UFCSPA), Porto Alegre, Brazil.
Bodee NuthoDepartment of Pharmacology, Faculty of Science, Mahidol University, Bangkok, Thailand.
Susanne MerkelDepartment of Surgery, Universitätsklinikum, Friedrich-Alexander Universität Erlangen-Nürnberg (FAU), Erlangen, Germany.
Arndt HartmannInstitute of Pathology, Universitätsklinikum, Friedrich-Alexander Universität Erlangen-Nürnberg (FAU), Erlangen, Germany.
Pithi ChanvorachoteCenter of Excellence in Cancer Cell and Molecular Biology, Faculty of Pharmaceutical Sciences, Chulalongkorn University, Bangkok, Thailand.
Regine Schneider-StockDepartment of Experimental Tumor Pathology, Universitätsklinikum, Friedrich-Alexander Universität Erlangen-Nürnberg (FAU), Erlangen, Germany.ORCID 0000-0003-0482-531X

Funding

Alexander von Humboldt-Stiftung THA-IPMahidol University (Basic Research Fund: fiscal year 2021) BRF1-A11/2564
6 · The paper itself

Abstract

Cancer stem cells (CSCs) drive tumor initiation, metastasis, and therapy resistance. The role of cytoplasmic cyclin-dependent kinase inhibitor 1A (CDKN1A, p21) in CSC biology remains unclear. Since cytoplasmic p21 correlated with advanced stage and metastasis in colorectal cancer (CRC) patients, we investigated its causal role in CSC features in vitro and in vivo. Cytoplasmic p21 increased spheroid formation and CD133 expression in a mechanism partly dependent on AKT activation. Phosphomimetic p21 (p21

Indexed as

Colonic NeoplasmsCyclin-Dependent Kinase Inhibitor p21CytoplasmNeoplastic Stem CellsNF-kappa BSignal TransductionAnimalsCell Line, TumorHumansMiceSpheroids, CellularCDKN1A protein, humanCyclin-Dependent Kinase Inhibitor p21NF-kappa BBCL‐xLCAM modelCD133IκBNFκBstem cells

Identifiers

PMID41178462
PMCPMC13060645

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.