ReviewHaematologica2025
Histiocyte Society blueprint for hemophagocytic lymphohistiocytosis research: deciphering underlying disease mechanisms to optimize diagnosis and therapy.
Review in Haematologica, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
9 citing papers in PubMed.
- Article
- Primary Hemophagocytic Lymphohistiocytosis: A Severe Immune Dysregulatory Disease with Various Genotypic Features and Outcomes: A Cross-Sectional Study from a Tertiary Pediatric CenterTurkish journal of haematology : official journal of Turkish Society of Haematology · 2026Article
- Article
- Early Risk Factors and Clinical Characteristics of Pediatric Hemophagocytic Lymphohistiocytosis: A Single-Center Retrospective Study.Journal of inflammation research · 2026Article
- Case Report: Hemophagocytic lymphohistiocytosis in an infant associated with cytomegalovirus infection and X-linked primary immunodeficiency.Frontiers in immunology · 2026Article
- Consensus recommendations for the diagnosis and management of hemophagocytic lymphohistiocytosis in the Gulf Cooperation Council: a modified Delphi approach.Frontiers in immunology · 2026Article
- Case Report: Hemophagocytic lymphohistiocytosis after SARS-CoV-2 infection revealing clinically diagnosed stage IVB diffuse large B-cell lymphoma in quiescent adult-onset Still's disease.Frontiers in immunology · 2026Article
- Introduction to the Review Series. Looking back and to the future: the Histiocyte Society blueprint for research in histiocytic disorders.Haematologica · 2025Article
- A critically ill adolescent with EBV-associated hemophagocytic lymphohistiocytosis-induced hyperinflammatory shock: a case report and literature review.Frontiers in immunology · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
Hemophagocytic lymphohistiocytosis (HLH) is a rare syndrome characterized by severe hyperinflammation, leading to endorgan damage and death in the absence of treatments directed at suppressing the overactive immune system. The study of mouse models and human biospecimens has provided insights into disease pathophysiology and enabled investigations of novel therapeutic strategies. Nevertheless, clinical outcomes remain suboptimal. Additional research is required to further our understanding of this highly heterogeneous disease in order to develop improved diagnostic and prognostic tools and identify and implement targeted and less toxic treatments. In this article, written on behalf of the Histiocyte Society, we highlight six key areas of ongoing research, including the remaining questions in each area. We also outline the challenges of global dissemination and implementation of this research and call for the establishment of local, regional, and national cooperative groups aimed at providing education for physicians and targeted diagnostic and clinical guidelines. Finally, we discuss the role of international societies, including the Histiocyte Society, in nucleating this work to ensure coordinated efforts aimed at improving outcomes for patients with HLH worldwide.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.