ArticleCirculation. Cardiovascular imaging2025
Multiparametric Contrast-Free MRI Successfully Identifies Venous Thrombus Responsive to Lytic Therapy: From Mice to Humans.
Article in Circulation. Cardiovascular imaging, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
2 citing papers in PubMed.
- Micro/Nanorobotic Systems for Imaging-Guided Closed-Loop Thrombus Recanalization.Cyborg and bionic systems (Washington, D.C.) · 2026Review
- Seeing the Unseen: Contrast-Free MRI for Predicting Thrombolytic Susceptibility.Circulation. Cardiovascular imaging · 2025Article
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Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundRandomized trials of venous thrombolysis to prevent postthrombotic syndrome have produced mixed results. A method to identify patients most likely to benefit from interventional treatment is needed. This study evaluated a contrast-free, magnetic resonance-based multisequence thrombus imaging (MSTI) technique to characterize deep venous thrombi and predict susceptibility to thrombolysis.
methodsVenous thrombosis was induced in the inferior vena cava of BALB/C mice (n=56, male), which were imaged up to 28 days postsurgery and 24 hours after systemic thrombolysis (Actilyse, 10 mg/kg, IV). The prelysis MSTI protocol included 3-dimensional T1 mapping, 3-dimensional magnetization transfer, and 2-dimensional diffusion-weighted imaging. Thrombolysis was defined as successful if inferior vena cava blood flow increased by ≥50% compared with prelysis values. In a clinical cohort, 41 patients with acute iliofemoral deep venous thrombi underwent MSTI before catheter-directed thrombolysis. Imaging parameters were analyzed against postintervention outcomes.
resultsMSTI identified thrombi susceptible to thrombolysis in both mice and humans. In mice, lysed thrombi showed lower T1 (723 [667-782] versus 874 [799-1000] ms;
conclusionsMSTI enables noninvasive, contrast-free characterization of thrombus composition and predicts thrombolytic susceptibility. This technique has the potential to guide patient selection for invasive therapies and should be incorporated into future trials of venous thrombosis treatment.
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