Evidence map›Paper›PMID 41178349›Full record

ArticleCancer discovery2025

The Bitter Aftertaste of Artificial Sweeteners in Cancer Immunotherapy.

Vidhi Chandra, Le Li, Florencia McAllister

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cancer discovery, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Vidhi ChandraDepartment of Genetics, University of Texas MD Anderson Cancer Center, Houston, Texas.ORCID 0000-0003-3642-2144
Le LiDepartment of Genetics, University of Texas MD Anderson Cancer Center, Houston, Texas.ORCID 0009-0007-5226-4875
Florencia McAllisterDepartment of Genetics, University of Texas MD Anderson Cancer Center, Houston, Texas.ORCID 0000-0002-9915-0943

Funding

Interrogating the Spatial and Functional Relevance of Microbes in Pancreatic Cancer and MetastasisR01CA282786 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI Florencia McAllister · 2024 to 2026
$2.7M
Dissecting the Source and Mechanisms of IL-17-Mediated Modulation of Pancreatic TumorigenesisR37CA237384 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI MCALLISTER, FLORENCIA · 2020 to 2025
$2.6M
NCI NIH HHS R01 CA282786NCI NIH HHS R37 CA237384
6 · The paper itself

Abstract

Morder, Nguyen, Wilfahrt, and colleagues report that nonnutritive sweeteners impair the efficacy of anti-PD-1 therapy through mechanisms that involve regulation of microbiota and metabolites. Their findings underscore the clinical relevance of long-term lifestyle interventions, such as limiting daily intake of nonnutritive sweeteners, across multiple cancer types. See related article by Morder et al., p. 2278.

Indexed as

ImmunotherapyNeoplasmsSweetening AgentsGastrointestinal MicrobiomeHumansImmune Checkpoint InhibitorsImmune Checkpoint InhibitorsSweetening Agents

Identifiers

PMID41178349
PMCPMC13267359

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.