Evidence map›Paper›PMID 41178269›Full record

ArticleMicrobiology and immunology2026

PGN_0298 in the Assembly and Insertion Machinery (Aim) Operon Is Essential for the Viability of Porphyromonas gingivalis.

Shintaro Ono, Katsuki Takebe, Ikue Tosa, Yuki Nishiya, Masaaki Nakayama, Takayuki Wada, Shogo Takashiba, Naoya Ohara

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Microbiology and immunology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Shintaro OnoDepartment of Oral Microbiology, Faculty of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, Okayama, Japan.ORCID https://orcid.org/0009-0001-1737-5058
Katsuki TakebeDepartment of Dental Pharmacology, Faculty of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, Okayama, Japan.ORCID https://orcid.org/0000-0002-1611-1042
Ikue TosaDepartment of Oral Microbiology, Faculty of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, Okayama, Japan.ORCID https://orcid.org/0000-0002-2649-661X
Yuki NishiyaDepartment of Oral and Maxillofacial Reconstructive Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, Okayama, Japan.ORCID https://orcid.org/0009-0003-4713-2254
Masaaki NakayamaDepartment of Oral Microbiology, Faculty of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, Okayama, Japan.ORCID https://orcid.org/0000-0001-9246-7801
Takayuki WadaGraduate School of Human Life and Ecology, Osaka Metropolitan University, Osaka, Japan.ORCID https://orcid.org/0000-0002-7023-7455
Shogo TakashibaDepartment of Pathophysiology-Periodontal Science, Faculty of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, Okayama, Japan.ORCID https://orcid.org/0000-0002-4712-6829
Naoya OharaDepartment of Oral Microbiology, Faculty of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, Okayama, Japan.ORCID https://orcid.org/0000-0003-3486-2373

Funding

JSPS KAKENHI Grant Number JP24K02614 (NO), JP23K15970 (SO), JP21K09842 (MN), JP24K23551 (KT).
6 · The paper itself

Abstract

Porphyromonas gingivalis is a typical periodontal pathogen, and one of its key virulence factors is the powerful protease gingipains. Gingipains are secreted via the type IX secretion system (T9SS) and are associated with the assembly and insertion machinery (Aim) operon (PGN_0296 to PGN_0301), which encodes both T9SS components and non-T9SS proteins. In this study, we investigated PGN_0298, a gene of unknown function within this operon, to elucidate its role in P. gingivalis and to gain insights into its potential function through bioinformatics analyses. Our results demonstrated that PGN_0298 is essential for the viability of P. gingivalis, despite having limited direct association with T9SS. Sequence homology and structure predictions indicate that PGN_0298 encodes a putative isoprenyl transferase. The essentiality of PGN_0298 underscores its potential as a novel drug target for the treatment of periodontal disease.

Indexed as

Bacterial ProteinsMicrobial ViabilityOperonPorphyromonas gingivalisAdhesins, BacterialBacterial Secretion SystemsComputational BiologyCysteine EndopeptidasesGingipain Cysteine EndopeptidasesHumansVirulence FactorsAdhesins, BacterialBacterial ProteinsBacterial Secretion SystemsCysteine EndopeptidasesGingipain Cysteine EndopeptidasesVirulence FactorsPGN_0298Porphyromonas gingivalisundecaprenyl pyrophosphate synthase

Identifiers

PMID41178269
PMCPMC12773653

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.