Evidence map›Paper›PMID 41178115›Full record

ArticleACS chemical neuroscience2025

Improving Proteostasis of Trafficking-Deficient GABA

Xu Fu, Ya-Juan Wang, KyungA Lee, Lucie Y Ahn, Xi Chen, Brock T Harvey, Meng Wang, Hailey Seibert, Pei-Pei Zhang, Adrian Guerrero and 5 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ACS chemical neuroscience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Xu FuDepartment of Physiology and Biophysics, Case Western Reserve University School of Medicine, 10900 Euclid Ave, Cleveland, Ohio 44106, United States.
Ya-Juan WangDepartment of Physiology and Biophysics, Case Western Reserve University School of Medicine, 10900 Euclid Ave, Cleveland, Ohio 44106, United States.
KyungA LeeDepartment of Chemistry, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, United States.
Lucie Y AhnDepartment of Genetics and Genome Sciences, Case Western Reserve University School of Medicine, Cleveland, Ohio 44106, United States.
Xi ChenDepartment of Physiology and Biophysics, Case Western Reserve University School of Medicine, 10900 Euclid Ave, Cleveland, Ohio 44106, United States.
Brock T HarveyDepartment of Chemistry, University of Kentucky, Lexington, Kentucky 40506, United States.
Meng WangDepartment of Physiology and Biophysics, Case Western Reserve University School of Medicine, 10900 Euclid Ave, Cleveland, Ohio 44106, United States.
Hailey SeibertDepartment of Physiology and Biophysics, Case Western Reserve University School of Medicine, 10900 Euclid Ave, Cleveland, Ohio 44106, United States.
Pei-Pei ZhangDepartment of Physiology and Biophysics, Case Western Reserve University School of Medicine, 10900 Euclid Ave, Cleveland, Ohio 44106, United States.
Adrian GuerreroDepartment of Chemistry, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, United States.
Ashleigh E SchafferDepartment of Genetics and Genome Sciences, Case Western Reserve University School of Medicine, Cleveland, Ohio 44106, United States.
Christopher I RichardsDepartment of Chemistry, University of Kentucky, Lexington, Kentucky 40506, United States.ORCID 0000-0003-0019-1989
R Luke WisemanDepartment of Molecular and Cellular Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, United States.ORCID 0000-0001-9287-6840
Jeffery W KellyDepartment of Chemistry, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, United States.ORCID 0000-0001-8943-3395
Ting-Wei MuDepartment of Physiology and Biophysics, Case Western Reserve University School of Medicine, 10900 Euclid Ave, Cleveland, Ohio 44106, United States.ORCID 0000-0002-6419-9296

Funding

Discovering small molecules activators of stress responsive signalingR01AG046495 · NIA · SCRIPPS RESEARCH INSTITUTE, THE · PI JEFFERY W KELLY, Rockland Luke Wiseman · 2013 to 2026
$6.0M
Understanding GABAA receptor protein folding and misfoldingR01NS105789 · NINDS · CASE WESTERN RESERVE UNIVERSITY · PI Tingwei Mu · 2018 to 2026
$3.9M
Discovering Small Molecule Activators of Stress-Responsive SignalingRF1AG046495 · NIA · SCRIPPS RESEARCH INSTITUTE, THE · PI KELLY, JEFFERY W, WISEMAN, ROCKLAND LUKE · 2023 to 2025
$2.8M
Role of small molecule interactions and multiprotein assemblies in CYP1B1 disease-associated function and dysfunctionR01GM138882 · NIGMS · UNIVERSITY OF KENTUCKY · PI GLAZER, EDITH C, HEIDARY, DAVID · 2020 to 2024
$1.9M
Assembly Chaperone Complex for Membrane Proteins in the Endoplasmic ReticulumR01NS117176 · NINDS · CASE WESTERN RESERVE UNIVERSITY · PI MU, TINGWEI · 2020 to 2023
$1.6M
Functional Genomics Training Program (FGTP)T32GM135081 · NIGMS · CASE WESTERN RESERVE UNIVERSITY · PI Thomas Louis LaFramboise, Helen C Miranda · 2020 to 2026
$1.3M
Ex vivo single molecule tools to analyze membrane receptor dynamicsR01GM138837 · NIGMS · UNIVERSITY OF KENTUCKY · PI RICHARDS, CHRISTOPHER I · 2021 to 2024
$1.2M
Proteostasis maintenance of neuroreceptors by an ER-phagy receptorR21NS145426 · NINDS · CASE WESTERN RESERVE UNIVERSITY · PI MU, TINGWEI · 2025 to 2025
$443k
NIA NIH HHS R01 AG046495NIA NIH HHS RF1 AG046495NIGMS NIH HHS R01 GM138837NIGMS NIH HHS R01 GM138882NIGMS NIH HHS T32 GM135081NINDS NIH HHS R01 NS105789NINDS NIH HHS R01 NS117176NINDS NIH HHS R21 NS145426
6 · The paper itself

Abstract

Gamma-aminobutyric acid type A receptors (GABA

Indexed as

EndoribonucleasesProtein Serine-Threonine KinasesProteostasisReceptors, GABA-AEndoplasmic ReticulumHEK293 CellsHumansProtein TransportUnfolded Protein ResponseX-Box Binding Protein 1EndoribonucleasesERN1 protein, humanGABRA1 protein, humanProtein Serine-Threonine KinasesReceptors, GABA-AX-Box Binding Protein 1epilepsyGABAA receptorsIRE1misfoldingproteostasisproteostasis regulators

Identifiers

PMID41178115
PMCPMC12679549

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.