Observational studyOral diseases2026
Salivary Proteomic Signatures in Pregnant Women With Excessive Gingival Bleeding.
Observational study in Oral diseases, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
3 citing papers in PubMed.
- High Gingival Bleeding Burden in Late Pregnancy Is Associated with a Salivary Profile of Inflammatory, Regulatory, and Stress-Response Signals.Life (Basel, Switzerland) · 2026Article
- Shotgun metagenomic mapping of saliva reveals insights into diversity and function of the oral microbiome in pregnancy.Scientific reports · 2026Article
- Salivary Proteomic Signatures in Pregnant Women With Excessive Gingival Bleeding.Oral diseases · 2026Observational
Corrections and comments
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Authors and funding
10 authors.
Funding
Abstract
objectiveThis observational, cross-sectional, and analytical study aimed to explore the pathophysiological mechanisms of gingivitis in pregnancy by analyzing the salivary proteomic profile according to gingival bleeding status. MATERIALS AND
methodsPregnant women at the 27th week of gestation or beyond were categorized into two groups: those with excessive gingival bleeding on probing (BOP > 50%; G1) and those without generalized gingivitis (BOP < 30%; G2). A comprehensive full-mouth periodontal examination was performed. Unstimulated whole-mouth saliva samples were collected and individually processed using Nano Liquid Chromatography Electron Spray Ionization Tandem Mass Spectrometry (nLC-ESI-MS/MS).
resultsProteomic analysis identified 187 salivary proteins, with 75 shared between groups. Sixty proteins were upregulated and seven were downregulated in G1. The most upregulated were Protein S100-A9 (16-fold), Neutrophil Defensins 1 and 3 (7-fold), Protein S100-A8 (5-fold), Beta-2-Microglobulin (4-fold), and multiple immunoglobulin isoforms. Histatin-3 was the only protein downregulated by more than 2-fold. Gene Ontology analysis revealed significant enrichment in processes related to antimicrobial humoral response, bacterial defense mechanisms, and immune regulation, reflecting the inflammatory state.
conclusionThese findings provide insights into the salivary proteomic alterations associated with generalized gingivitis in pregnancy, particularly highlighting immune and antimicrobial pathways linked to excessive gingival inflammation.
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Registered trials
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