ArticleEuropean journal of medical research2025
Tissue inhibitor of metalloproteinase-2 predicts early allograft dysfunction after liver transplantation.
Article in European journal of medical research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- Pathophysiological mechanisms of cell death affecting graft survival in liver transplantation.World journal of transplantation · 2026Review
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4 authors.
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Abstract
backgroundThe lack of objective criteria to assess graft integrity represents a major impediment to the acceptance of livers of limited quality as a way to increase the donor pool in liver transplantation. Extracorporeal machine perfusion prior to transplantation may serve as a valuable platform to second to the surgeon's decision on acceptance or discard of the organ, but, to date, the availability of valuable perfusate biomarkers is rather poor. Tissue inhibitor of metalloproteinase-2 (TIMP2) is a protein actively secreted upon epithelial cell stress and involved in the suppression of endothelial cell proliferation.
methodsA total of 20 livers grafts from extended criteria donors, which were shipped to the implantation clinic by conventional cold storage, were subjected to 90 min of ex vivo machine perfusion after arrival. At the end of liver perfusion, perfusate concentrations of TIMP2 were measured and related to the occurrence of early allograft dysfunction after transplantation.
resultsROC analysis disclosed a significant (p = 0.0046; CI 0.9-0.1) predictive potential of TIMP2 with a sensitivity to predict EAD of 1.0 (CI 0.51-1.0) and a specificity of 0.94 (CI 0.72-1.0) at a cut-off value of 2106 pg/ml.
conclusionsDetermination of TIMP2, which is possible to be performed as point-of-care measure, may thus become a useful adjunct on the way to better evaluate extended criteria donor livers.
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