Evidence map›Paper›PMID 41177850›Full record

ArticleEuropean journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology2026

Whole-genome characterisation of Escherichia coli isolates from older women with urinary tract infection and asymptomatic bacteriuria.

Marlies Mulder, Manu P Bilsen, Martha T van der Beek, Antoni P A Hendrickx, Angela de Haan, Merel M C Lambregts, Caroline Schneeberger-van der Linden

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Article in European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

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0cells of the map it votes in
2citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Cytolethal distending toxin enhancesInfection and immunity · 2026
    Article
  2. Cytolethal Distending Toxin EnhancesbioRxiv : the preprint server for biology · 2026
    Article
4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Marlies MulderDepartment of Medical Microbiology, Infectious Diseases and Infection Prevention, Maastricht University Medical Centre (MUMC+), Maastricht, The Netherlands. marlies.mulder@mumc.nl.
Manu P BilsenLeiden University Center of Infectious Diseases (LUCID), Leiden University Medical Center, Leiden, The Netherlands.
Martha T van der BeekLeiden University Center of Infectious Diseases (LUCID), Leiden University Medical Center, Leiden, The Netherlands.
Antoni P A HendrickxNational Institute for Public Health and the Environment (RIVM), Centre for Infectious Disease Control, Bilthoven, the Netherlands.
Angela de HaanNational Institute for Public Health and the Environment (RIVM), Centre for Infectious Disease Control, Bilthoven, the Netherlands.
Merel M C LambregtsLeiden University Center of Infectious Diseases (LUCID), Leiden University Medical Center, Leiden, The Netherlands.
Caroline Schneeberger-van der LindenDepartment of Medicine for Older People, Amsterdam UMC Location Vrije Universiteit, Amsterdam, The Netherlands.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesDiagnosing urinary tract infections (UTIs) in older women is challenging due to the high prevalence of asymptomatic bacteriuria (ASB). This study aimed to investigate whether pathogen-related factors differ between older women with UTI and those with ASB, and to gain further insight into the persistence of Escherichia coli in ASB.

methodsIn this exploratory study, E. coli isolates from 46 participants were analysed. The study included community-dwelling and long-term care facility women aged ≥ 65 years diagnosed with either UTI (defined as ≥ 2 new-onset lower urinary tract symptoms, pyuria, and bacteriuria) or ASB (E. coli ≥ 10

resultsWe analysed 31 isolates from UTI patients and 32 sequential isolates from 15 ASB patients. All ASB patients carried genetically similar E. coli strains in two consecutive samples taken 2-4 weeks apart. The isolates represented a diverse range of STs, with ST69, ST73, and ST141 being the most prevalent. Although no significant difference in the overall number of PUFs between UTI and ASB groups was observed, distinct patterns emerged. UTI-associated isolates more frequently harbored cnf1 and sfaH, whereas iha, iucC and sat were more common in ASB isolates.

conclusionsOur findings suggest potential individual differences in the presence of PUFs between UTI and ASB isolates. Further functional studies are warranted to explore the role of these factors in bladder colonization and UTI pathogenesis. Additionally, their interactions with host-specific factors should be examined to better understand bacterial persistence and disease development in older women.

Indexed as

BacteriuriaEscherichia coliEscherichia coli InfectionsGenome, BacterialUrinary Tract InfectionsAgedAged, 80 and overAsymptomatic InfectionsFemaleHumansMultilocus Sequence TypingVirulence FactorsWhole Genome SequencingVirulence FactorsAsymptomatic bacteriuriaEscherichia coliOlder adultsUrinary tract infectionVirulence factorsWGS

Identifiers

PMID41177850

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.