Evidence map›Paper›PMID 41177836›Full record

ArticleEuropean journal of nuclear medicine and molecular imaging2026

Exceptional brain PET images from the NeuroEXPLORER: scans with targeted radiopharmaceuticals and comparison to HRRT.

Tommaso Volpi, Takuya Toyonaga, Nikkita Khattar, Jean-Dominique Gallezot, Mika Naganawa, Greet Vanderlinden, Praveen Honhar, Tianyi Zeng, Kathryn Fontaine, Tim Mulnix and 20 more

Abstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in European journal of nuclear medicine and molecular imaging, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Eagle eyes on the human brain and beyond: PET at ultra-high spatial resolution.European journal of nuclear medicine and molecular imaging · 2026
    Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

30 authors.

Tommaso VolpiDepartment of Radiology, Yale University, New Haven, CT, 06501, USA. tommaso.volpi@yale.edu.ORCID 0000-0002-5451-6710
Takuya ToyonagaDepartment of Radiology, Yale University, New Haven, CT, 06501, USA.
Nikkita KhattarDepartment of Radiology, Yale University, New Haven, CT, 06501, USA.
Jean-Dominique GallezotDepartment of Radiology, Yale University, New Haven, CT, 06501, USA.
Mika NaganawaDepartment of Radiology, Yale University, New Haven, CT, 06501, USA.
Greet VanderlindenNuclear Medicine and Molecular Imaging, Imaging Pathology, KU Leuven, Louvain, Belgium.
Praveen HonharDepartment of Radiology, Yale University, New Haven, CT, 06501, USA.
Tianyi ZengDepartment of Radiology, Yale University, New Haven, CT, 06501, USA.
Kathryn FontaineDepartment of Radiology, Yale University, New Haven, CT, 06501, USA.
Tim MulnixDepartment of Radiology, Yale University, New Haven, CT, 06501, USA.
Lingzhi HuUnited Imaging Healthcare America, Houston, TX, 77002, USA.
Xishan SunUnited Imaging Healthcare America, Houston, TX, 77002, USA.
Shannan HenryDepartment of Radiology, Yale University, New Haven, CT, 06501, USA.
David MatuskeyDepartment of Radiology, Yale University, New Haven, CT, 06501, USA.
Rajiv RadhakrishnanYale Biomedical Imaging Institute, PET Core, Yale University, New Haven, CT, 06501, USA.
Liang GuoDepartment of Radiology, Yale University, New Haven, CT, 06501, USA.
Yifan HuDepartment of Radiology, Yale University, New Haven, CT, 06501, USA.
Jiazhen ZhangDepartment of Radiology, Yale University, New Haven, CT, 06501, USA.
Xinyuan ZhengDepartment of Radiology, Yale University, New Haven, CT, 06501, USA.
Nabeel NabulsiDepartment of Radiology, Yale University, New Haven, CT, 06501, USA.
Yiyun HuangDepartment of Radiology, Yale University, New Haven, CT, 06501, USA.
Ramsey D BadawiDepartment of Radiology, Department of Biomedical Engineering, University of California Davis, Davis, CA, 95616, USA.
Simon R CherryDepartment of Radiology, Department of Biomedical Engineering, University of California Davis, Davis, CA, 95616, USA.
Ansel T HillmerDepartment of Radiology, University of Michigan, Ann Arbor, MI, 48103, USA.
Terry JonesDepartment of Radiology, Department of Biomedical Engineering, University of California Davis, Davis, CA, 95616, USA.
Chi LiuDepartment of Radiology, Yale University, New Haven, CT, 06501, USA.
Evan MorrisDepartment of Radiology, Yale University, New Haven, CT, 06501, USA.
Jinyi QiDepartment of Radiology, Department of Biomedical Engineering, University of California Davis, Davis, CA, 95616, USA.
Hongdi LiUnited Imaging Healthcare America, Houston, TX, 77002, USA.
Richard E CarsonDepartment of Radiology, Yale University, New Haven, CT, 06501, USA.

Funding

NeuroExplorer: Ultra-high Performance Human Brain PET Imager for Highly-resolved In Vivo Imaging of NeurochemistryU01EB029811 · NIBIB · YALE UNIVERSITY · PI CARSON, RICHARD E., LI, HONGDI · 2020 to 2024
$10.0M
NIBIB NIH HHS U01 EB029811NIBIB NIH HHS U01EB029811
6 · The paper itself

Abstract

purposeCurrent brain-dedicated positron emission tomography (PET) systems (e.g., the High-Resolution Research Tomograph, HRRT) are unable to accurately and precisely measure pharmacologically-specific signals in small brain regions due to insufficient image resolution and sensitivity. The NeuroEXPLORER (NX), a new ultra-high-performance brain-dedicated scanner, promises to address these needs.

methodsSeven healthy individuals underwent paired scans on the HRRT and NX with targeted radiopharmaceuticals (

resultsThe exceptional spatial resolution of the NX can be appreciated in the details of the cortical ribbon and subcortical nuclei (e.g., mediodorsal thalamus) for

conclusionWe compared measurements of tracer uptake between an ultra-high-performance brain-dedicated PET system (NX) and the previous state-of-the-art system (HRRT) in the same subjects for seven different tracers, demonstrating a substantial gain in image detail, especially for small brain structures. We also discussed the implications of this technology for basic and clinical brain PET research and potential healthcare applications. CLINICAL TRIAL NUMBER: Not applicable.

Indexed as

BrainPositron-Emission TomographyRadiopharmaceuticalsAdultFemaleHumansMaleMiddle AgedRadiopharmaceuticalsBrain PETHigh resolutionHRRTNeuroEXPLORERSmall nuclei

Identifiers

PMID41177836
PMCPMC12860869

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.