Evidence map›Paper›PMID 41177827›Full record

ArticleAnnals of hematology2025

Expansion of peripheral helper T cells in the peripheral blood of patients with chronic graft-versus-host disease.

Yuanyuan Du, Xuefeng He, Kangkang Lv, Youzhen Ge, Mimi Xu, Li Wan, Meng Zhou, Huizhu Kang, Chengyuan Gu, Ruju Wang and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Annals of hematology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Yuanyuan DuNational Clinical Research Center for Hematologic Diseases, Jiangsu Institute of Hematology, The First Affiliated Hospital of Soochow University, Suzhou, China.
Xuefeng HeNational Clinical Research Center for Hematologic Diseases, Jiangsu Institute of Hematology, The First Affiliated Hospital of Soochow University, Suzhou, China.
Kangkang LvNational Clinical Research Center for Hematologic Diseases, Jiangsu Institute of Hematology, The First Affiliated Hospital of Soochow University, Suzhou, China.
Youzhen GeInstitute of Blood and Marrow Transplantation, Collaborative Innovation Center of Hematology, Soochow University, Suzhou, China.
Mimi XuNational Clinical Research Center for Hematologic Diseases, Jiangsu Institute of Hematology, The First Affiliated Hospital of Soochow University, Suzhou, China.
Li WanDepartment of Transfusion Medicine, Wuhan Hospital of Traditional Chinese and Western Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Meng ZhouNational Clinical Research Center for Hematologic Diseases, Jiangsu Institute of Hematology, The First Affiliated Hospital of Soochow University, Suzhou, China.
Huizhu KangNational Clinical Research Center for Hematologic Diseases, Jiangsu Institute of Hematology, The First Affiliated Hospital of Soochow University, Suzhou, China.
Chengyuan GuNational Clinical Research Center for Hematologic Diseases, Jiangsu Institute of Hematology, The First Affiliated Hospital of Soochow University, Suzhou, China.
Ruju WangNational Clinical Research Center for Hematologic Diseases, Jiangsu Institute of Hematology, The First Affiliated Hospital of Soochow University, Suzhou, China.
Yue HanNational Clinical Research Center for Hematologic Diseases, Jiangsu Institute of Hematology, The First Affiliated Hospital of Soochow University, Suzhou, China.
Yongxia WuDepartment of Microbiology & Immunology, Medical College of Wisconsin, Milwaukee, USA.
Depei WuNational Clinical Research Center for Hematologic Diseases, Jiangsu Institute of Hematology, The First Affiliated Hospital of Soochow University, Suzhou, China.
Yuejun LiuNational Clinical Research Center for Hematologic Diseases, Jiangsu Institute of Hematology, The First Affiliated Hospital of Soochow University, Suzhou, China. liuyuejun@suda.edu.cn.

Funding

Boxi Clinical Research of the First Affiliated Hospital of Soochow University BXLC2024028Collaborative Projects of Soochow University P112204622National Natural Science Foundation of China 82370214
6 · The paper itself

Abstract

Chronic graft-versus-host disease (cGVHD), presented as an autoimmune-like syndrome, is an important late complication and has become the leading cause of non-recurrent death after allogeneic hematopoietic stem cell transplantation (allo-HSCT). A cohort of 52 cGVHD patients were analyzed for the presence of Tph cells, circulating follicular helper T (cTfh) cells and B cells in peripheral blood mononuclear cells (PBMCs). We found decreased frequency of cTfh cells, but increased frequency of Tph cells in post-transplant patients compared to healthy controls (HCs). Higher percentage and absolute number of CCR2

Indexed as

Graft vs Host DiseaseHematopoietic Stem Cell TransplantationT-Lymphocytes, Helper-InducerAdultAgedB-LymphocytesChronic DiseaseFemaleHumansMaleMiddle AgedYoung AdultAllogeneic hematopoietic stem cell transplantationB cellsChronic graft-versus-host diseasePeripheral helper t cells

Identifiers

PMID41177827
PMCPMC12619759

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.