Evidence map›Paper›PMID 41176968›Full record

ArticleVaccine2025

Preventive effect of vaccination on long COVID in adolescents with SARS-CoV-2 infection.

Tanayott Thaweethai, Rachel S Gross, Deepti B Pant, Kyung E Rhee, Terry L Jernigan, Lawrence C Kleinman, Jessica N Snowden, Amy L Salisbury, Patricia A Kinser, Joshua D Milner and 11 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Vaccine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Observational
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors.

Tanayott ThaweethaiMassachusetts General Hospital Biostatistics, 399 Revolution Drive, Suite 1068, Somerville, MA 02145, USA; Department of Medicine, Harvard Medical School, 25 Shattuck Street, Boston, MA 02115, USA. Electronic address: tthaweethai@mgh.harvard.edu.
Rachel S GrossDivision of General Pediatrics, Department of Pediatrics, NYU Grossman School of Medicine, 227 East 30(th) Street, 6th Floor, New York, NY 10016, USA. Electronic address: Rachel.Gross@nyulangone.org.
Deepti B PantMassachusetts General Hospital Biostatistics, 399 Revolution Drive, Suite 1068, Somerville, MA 02145, USA. Electronic address: dpant1@mgh.harvard.edu.
Kyung E RheeDivision of Child and Community Health, Department of Pediatrics, UC San Diego School of Medicine, 9500 Gilman Dr, MC 0874, La Jolla, CA 92093, USA. Electronic address: k1rhee@health.ucsd.edu.
Terry L JerniganDepartments of Cognitive Science, Psychiatry, and Radiology, and Center for Human Development, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA. Electronic address: tjernigan@ucsd.edu.
Lawrence C KleinmanDivision of Population Health, Quality, and Implementation Sciences (PopQuIS), Department of Pediatrics, Child Health Institute of New Jersey, Rutgers Robert Wood Johnson Medical School, 89 French Street, Room 1201, New Brunswick, NJ 08901, USA; Bristol Myers Squibb Children's Hospital, 200 Somerset Street, New Brunswick, NJ 08901, USA. Electronic address: lk157@rwjms.rutgers.edu.
Jessica N SnowdenDivision of Infectious Diseases, Department of Pediatrics, University of Arkansas for Medical Sciences, 4301 West Markham Street, Little Rock, AR 72205, USA. Electronic address: jsnowde2@uthsc.edu.
Amy L SalisburySchool of Nursing, Virginia Commonwealth University, 1100 E Leigh St, Richmond, VA 23298, USA. Electronic address: salisburya@vcu.edu.
Patricia A KinserSchool of Nursing, Virginia Commonwealth University, 1100 E Leigh St, Richmond, VA 23298, USA. Electronic address: kinserpa@vcu.edu.
Joshua D MilnerDivision of Allergy, Immunology and Rheumatology, Department of Pediatrics, Columbia University Vagelos College of Physicians and Surgeons, 622 West 168th Street Presbyterian Hospital Building, PH-17, New York, NY 10032, USA; NewYork-Presbyterian Hospital, 622 West 168th Street, New York, NY 10032, USA. Electronic address: jdm2249@cumc.columbia.edu.
Kelan TantisiraDivision of Respiratory Medicine, Department of Pediatrics, UC San Diego School of Medicine, Rady Children's Hospital, 3030 Children's Way 2nd Floor, San Diego, CA 92123, USA. Electronic address: ktantisira@health.ucsd.edu.
David WarburtonChildren's Hospital Los Angeles, Keck School of Medicine, University of Southern California, 4650 Sunset Blvd, Los Angeles, CA 90027, USA. Electronic address: DWarburton@chla.usc.edu.
Sindhu MohandasDivision of Infectious Diseases, Department of Pediatrics, Children's Hospital Los Angeles, Keck School of Medicine, University of Southern California, 4650 Sunset Blvd, Los Angeles, CA 90027, USA. Electronic address: smohandas@chla.usc.edu.
John C WoodDivision of Cardiology, Department of Pediatrics, Children's Hospital Los Angeles, Keck School of Medicine, University of Southern California, Los Angeles, CA, 4650 Sunset Blvd, Los Angeles, CA 90027, USA. Electronic address: JWood@chla.usc.edu.
Megan L FitzgeraldRECOVER Patient, Caregiver, or Community Advocate Representative, 550 1st Ave, New York, NY 10016, USA; Patient Led Research Collaborative, 23564 Calabasas Road, Suite 201, Calabasas, CA 91302, USA.
Megan CarmilaniRECOVER Patient, Caregiver, or Community Advocate Representative, 550 1st Ave, New York, NY 10016, USA; Long Covid Families, Charlotte, NC, United States.
Aparna KrishnamoorthyMassachusetts General Hospital Biostatistics, 399 Revolution Drive, Suite 1068, Somerville, MA 02145, USA. Electronic address: AKRISHNAMOORTHY2@mgh.harvard.edu.
Harrison T ReederMassachusetts General Hospital Biostatistics, 399 Revolution Drive, Suite 1068, Somerville, MA 02145, USA; Department of Medicine, Harvard Medical School, 25 Shattuck Street, Boston, MA 02115, USA. Electronic address: HREEDER@mgh.harvard.edu.
Andrea S FoulkesMassachusetts General Hospital Biostatistics, 399 Revolution Drive, Suite 1068, Somerville, MA 02145, USA; Department of Medicine, Harvard Medical School, 25 Shattuck Street, Boston, MA 02115, USA; Department of Biostatistics, Harvard T.H. Chan School of Public Health, 655 Huntington Avenue Building 2, 4th Floor, Boston, MA 02115, USA. Electronic address: AFOULKES@mgh.harvard.edu.
Melissa S StockwellNewYork-Presbyterian Hospital, 622 West 168th Street, New York, NY 10032, USA; Division of Child and Adolescent Health, Department of Pediatrics, Columbia University Vagelos College of Physicians and Surgeons, 622 West 168th Street Presbyterian Hospital Building, PH-17, New York, NY 10032, USA; Department of Population and Family Health, Mailman School of Public Health, New York-Presbyterian Hospital, 722 West 168th Street, New York, NY 10032, USA. Electronic address: mss2112@cumc.columbia.edu.
RECOVER-Pediatrics Consortium

Funding

ACTIV Integration of Host-targeting Therapies for COVID-19 Administrative Coordinating CenterOT2HL156812 · NHLBI · RESEARCH TRIANGLE INSTITUTE · PI NOLEN, TRACY L, THOMAS, SONIA M · 2020 to 2024
$1270.7M
OTA-21-015A Post-Acute Sequelae of SARS-CoV-2 Infection Initiative: NYU Langone Health Clinical Science Core, Data Resource Core, and PASC Biorepository CoreOT2HL161847 · NHLBI · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI GROSS, RACHEL SHARON, HORWITZ, LEORA · 2021 to 2025
$651.0M
Interactive Data Portals and Robust Analytic Tools to Wrap PASC Cohorts (iDRAW) OTA-21-015AOT2HL161841 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI FOULKES, ANDREA S, KARLSON, ELIZABETH W · 2021 to 2024
$182.2M
ABCD-USA Consortium: Coordinating CenterU24DA041147 · NIDA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI SANDRA A BROWN, TERRY L. JERNIGAN · 2015 to 2026
$54.7M
ABCD-USA Consortium: Data Analysis, Informatics and Resource CenterU24DA041123 · NIDA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI ANDERS M DALE · 2015 to 2026
$51.5M
Adolescent Substance Use Initiation: Disentangling neurocognitive risks from consequences using longitudinal and genetically-informed methodsU01DA041120 · NIDA · UNIVERSITY OF MINNESOTA · PI Monica Luciana, Sylia Wilson · 2015 to 2026
$34.5M
ABCD-USA Consortium: Research ProjectU01DA041089 · NIDA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Joanna Jacobus, Susan F. Tapert · 2015 to 2026
$31.7M
Prospective Research Studies of Maturation (PRISM)- Research ProjectU01DA041134 · NIDA · UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH · PI ERIN MCGLADE, PERRY FRANKLIN RENSHAW · 2015 to 2026
$29.2M
ABCD-USA CONSORTIUM: RESEARCH PROJECTU01DA041048 · NIDA · CHILDREN'S HOSPITAL OF LOS ANGELES · PI Megan Marie Herting, ELIZABETH R SOWELL · 2015 to 2026
$28.7M
ABCD-USA Consortium: Research ProjectU01DA041106 · NIDA · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Mary M Heitzeg, Chandra Sekhar Sripada · 2015 to 2026
$24.9M
FIU-ABCD: Pathways and Mechanisms to Addiction in the Latino Youth of South FloridaU01DA041156 · NIDA · FLORIDA INTERNATIONAL UNIVERSITY · PI Raul Gonzalez, Angela R Laird · 2015 to 2026
$22.8M
ABCD-USA Consortium: Research ProjectU01DA041148 · NIDA · OREGON HEALTH & SCIENCE UNIVERSITY · PI Damien A Fair, Rebekah S Huber · 2015 to 2026
$22.3M
NHLBI NIH HHS OT2 HL156812NHLBI NIH HHS OT2 HL161841NHLBI NIH HHS OT2 HL161847NIDA NIH HHS U01 DA041022NIDA NIH HHS U01 DA041025NIDA NIH HHS U01 DA041028NIDA NIH HHS U01 DA041048NIDA NIH HHS U01 DA041089NIDA NIH HHS U01 DA041093NIDA NIH HHS U01 DA041106NIDA NIH HHS U01 DA041117NIDA NIH HHS U01 DA041120NIDA NIH HHS U01 DA041134NIDA NIH HHS U01 DA041148NIDA NIH HHS U01 DA041156NIDA NIH HHS U01 DA041174NIDA NIH HHS U01 DA050987NIDA NIH HHS U01 DA050988NIDA NIH HHS U01 DA050989NIDA NIH HHS U01 DA051016NIDA NIH HHS U01 DA051018NIDA NIH HHS U01 DA051037NIDA NIH HHS U01 DA051038NIDA NIH HHS U01 DA051039NIDA NIH HHS U24 DA041123NIDA NIH HHS U24 DA041147
6 · The paper itself

Abstract

purposeIn adolescents (12-17 years), it is unknown whether COVID-19 vaccination reduces progression from COVID-19 to Long COVID (LC) beyond preventing SARS-CoV-2 infection. We assessed the effect of vaccination among SARS-CoV-2 infected adolescents. METHODS AND

resultsParticipants were recruited from over 60 US healthcare and community settings. The exposure was any COVID-19 vaccination 6 months prior to infection. The outcome was LC defined using the LC research index. Vaccinated (n = 724) and unvaccinated (n = 507) adolescents were matched on sex, infection date, and enrollment date. The risk of LC was 36 % lower (95 % CI, 17 %, 50 %) in vaccinated compared to unvaccinated participants.

conclusionsVaccination reduces the risk of LC. Given the profound impact LC can have on the health and well-being of adolescents and the limited availability of treatments during this developmental stage, this supports vaccination as a strategy for preventing LC by demonstrating an important secondary prevention effect.

Indexed as

COVID-19COVID-19 VaccinesVaccinationAdolescentChildDisease ProgressionFemaleHumansMaleSARS-CoV-2United StatesCOVID-19 VaccinesAdolescent healthCOVID-19Long COVIDSecondary preventionVaccination

Identifiers

PMID41176968
PMCPMC12670331

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.