ArticleBiophysical journal2025
Mechanically gated currents in mouse sensory neurons lacking PIEZO2.
Article in Biophysical journal, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed.
- Cold-gated potentiation of mechanotransduction supports touch sensation below 5°C in a mammalian hibernator.Current biology : CB · 2026Article
- Piezo2-Initiated Ultrafast Signaling and Its Acquired Channelopathy in Light of Quantum Gravity Theory.International journal of molecular sciences · 2026Review
- PIEZO2 in tumors: from mechanobiological switches to activity-targeted therapies.Journal of experimental & clinical cancer research : CR · 2025Review
- Biomechanical Model of Non-Contact Anterior Cruciate Ligament Injury Concerning Shin Angle and Field Surface Traction Parameters-With a Piezo2 Interpretation.Sports (Basel, Switzerland) · 2025Article
- Genetic Variants inInternational journal of molecular sciences · 2025Article
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Touch sensation starts with the opening of mechanically gated activated ion channels at neuroglial endings of mechanoreceptors in the skin. The function of around half of low-threshold mechanoreceptors is dependent on the presence of the mechanically gated ion channel PIEZO2. It has been reported that particularly rapidly adapting mechanosensitive currents (RA currents) in the cell bodies of acutely cultured sensory neurons are dependent on PIEZO2. Here we re-examined this question by making a quantitative study of mechanically gated currents activated by substrate deflection in sensory neurons lacking PIEZO2. We characterized mechanically gated currents from embryonic and postnatal sensory neurons, taken from global Piezo2
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