Evidence map›Paper›PMID 41176577›Full record

ArticleMolecular diversity2026

Synthesis and antitumor evaluation of oleanolic acid acylhydrazone derivatives.

Juan Cai, Bo-Wen Pan, Liang-Liang Zheng, You-Ping Tian, Zhang-Chao Dong, Li-Juan Liu, Ting-Ting Feng, Ying Zhou, Xiong-Wei Liu, Yang Shi

Abstract read
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In one paragraph

Article in Molecular diversity, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Juan Cai *College of Pharmacy, Guizhou University of Traditional Chinese Medicine, Guiyang, 550025, China.
Bo-Wen Pan *College of Pharmacy, Guizhou University of Traditional Chinese Medicine, Guiyang, 550025, China.
Liang-Liang Zheng *Qiandongnan Prefecture Food and Drug Inspection and Testing Center, Kaili, 556011, China.
You-Ping TianCollege of Pharmacy, Guizhou University of Traditional Chinese Medicine, Guiyang, 550025, China.
Zhang-Chao DongCollege of Pharmacy, Guizhou University of Traditional Chinese Medicine, Guiyang, 550025, China.
Li-Juan LiuCollege of Pharmacy, Guizhou University of Traditional Chinese Medicine, Guiyang, 550025, China.
Ting-Ting FengCollege of Pharmacy, Guizhou University of Traditional Chinese Medicine, Guiyang, 550025, China.
Ying ZhouCollege of Pharmacy, Guizhou University of Traditional Chinese Medicine, Guiyang, 550025, China. yingzhou71@126.com.
Xiong-Wei LiuCollege of Pharmacy, Guizhou University of Traditional Chinese Medicine, Guiyang, 550025, China. liuxiongwei058@gzy.edu.cn.
Yang ShiCollege of Pharmacy, Guizhou University of Traditional Chinese Medicine, Guiyang, 550025, China. xiaoyewater@163.com.

Funding

Guizhou Provincial Administration of Traditional Chinese Medicine QZYY-2024-130Guizhou Provincial Association for Science and Technology GASTYESS202439Guizhou Provincial Science and Technology Department latform Talent-CXTD[2023]020Guizhou Provincial Science and Technology Department Qian Ke He Platform ZSYS [2025] 019Guizhou Provincial Science and Technology Department ZK[20244] general 370Science and Technology Bureau, Guiyang Municipal Government [2024]2-37State Key Laboratory of Natural and Biomimetic Drugs K202428uizhou Provincial Department of Education Qianjiaoji [2023] 069
6 · The paper itself

Abstract

Cancer is the second leading cause of death worldwide, highlighting the urgent need for novel therapeutic strategies and targeted drug development. Oleanolic acid (OA) is a natural compound with notable antitumor activity. This study aimed to develop OA derivatives with enhanced antitumor potency through structural optimization and biological evaluation. First, modifications were introduced at the C28 carboxylic acid group of OA to generate a series of acylhydrazone derivatives. Their structures were confirmed via ¹H NMR,

Indexed as

Antineoplastic AgentsHydrazonesOleanolic AcidCell Line, TumorCell ProliferationDrug Screening Assays, AntitumorHumansMolecular Docking SimulationStructure-Activity RelationshipAntineoplastic AgentsHydrazonesOleanolic AcidAntitumor activity evaluationMolecular dockingNetwork pharmacologyOleanolic acidStructural modification

Identifiers

PMID41176577

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.