Evidence map›Paper›PMID 41176560›Full record

SynthesisEuropean archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery2025

Efficacy and safety of serial intralesional corticosteroids for subglottic stenosis: systematic review & meta-analysis.

Sarah Almansour, Manal Bukhari, Mohammad Almohizea, Faisal Zagzoog, Atheer Alsufyani, Razan Alosaimi, Fatimah Al Angari

Abstract readSystematic ReviewMeta-Analysis
PubMed Publisher
In one paragraph

Synthesis in European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Sarah AlmansourDepartment of Otolaryngology Head and Neck Surgery, College of Medicine, King Saud University, Riyadh, Central Region, Saudi Arabia. sarah.a.almansour@gmail.com.ORCID http://orcid.org/0000-0002-2817-4008
Manal Bukhari *Department of Otolaryngology Head and Neck Surgery, College of Medicine, King Saud University, Riyadh, Central Region, Saudi Arabia.
Mohammad Almohizea *Department of Otolaryngology Head and Neck Surgery, College of Medicine, King Saud University, Riyadh, Central Region, Saudi Arabia.
Faisal Zagzoog *Department of Otolaryngology Head and Neck Surgery, King Abdulaziz University, College of Medicine, King Abdulaziz University Hospital, Jeddah, Western Region, Saudi Arabia.
Atheer Alsufyani *Department of Otolaryngology Head and Neck Surgery, College of Medicine, King Saud University, Riyadh, Central Region, Saudi Arabia.
Razan Alosaimi *Department of Otolaryngology Head and Neck Surgery, College of Medicine, King Saud University, Riyadh, Central Region, Saudi Arabia.
Fatimah Al Angari *Department of Otolaryngology Head and Neck Surgery, College of Medicine, King Saud University, Riyadh, Central Region, Saudi Arabia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveWe conducted this systematic review and meta-analysis to investigate the efficacy and safety of the use of serial intralesional steroid injection (SILSI) in patients with subglottic stenosis (SGS). DATA SOURCES: PubMed, Web of Science, and Scopus databases, from inception until December 2024. REVIEW

methodsDatabase search used the following keywords: "Subglottic stenosis" AND "Intralesional." The meta-analysis pooled the mean difference (MD) and standardized mean difference (SMD) for outcomes measured on different scales, based on pre-operative and post-operative values, with 95% confidence interval (CI). For categorical variables, we used Open MetaAnalyst software to calculate the rate of different outcomes and the effect estimates. Heterogeneity was assessed using the I

resultsThe use of SILSI in SGS patients increases the surgery-free survival duration with a MD = 395.27 days (95% CI: 166.14, 624.39, p = 0.0007), I

conclusionSILSI has shown a high success rate, extended surgery-free survival, and improved PEF, with a relatively low recurrence rate and minimal risk of adverse events. Given this high efficacy and favorable safety profile, SILSI is recommended for use in SGS.

Indexed as

Adrenal Cortex HormonesGlucocorticoidsLaryngostenosisHumansInjections, IntralesionalTreatment OutcomeAdrenal Cortex HormonesGlucocorticoidsCorticosteroidsEfficacyIntralesionalSafetySerialSubglottic stenosis

Identifiers

PMID41176560

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.