Evidence map›Paper›PMID 41176553›Full record

ArticleEuropean radiology2026

6-Deoxy-6-[

Tianhong Yang, Songhan Ge, Zhifeng Chen, Yuying Zhang, Kunyuan Jiang, Bing Zhang, Weian Chen, Jianbo Liu, Xiangdong Xu, Zhihao Zha and 1 more

Abstract readComparative Study
PubMed Publisher
In one paragraph

Article in European radiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Tianhong Yang *Department of Nuclear Medicine, The First Affiliated Hospital, Sun Yat-Sen University, Guangzhou, Guangdong, China.
Songhan Ge *Department of Nuclear Medicine, The First Affiliated Hospital, Sun Yat-Sen University, Guangzhou, Guangdong, China.
Zhifeng Chen *Department of Nuclear Medicine, The First Affiliated Hospital, Sun Yat-Sen University, Guangzhou, Guangdong, China.
Yuying ZhangDepartment of Nuclear Medicine, The First Affiliated Hospital, Sun Yat-Sen University, Guangzhou, Guangdong, China.
Kunyuan JiangDepartment of Nuclear Medicine, The First Affiliated Hospital, Sun Yat-Sen University, Guangzhou, Guangdong, China.
Bing ZhangDepartment of Nuclear Medicine, The First Affiliated Hospital, Sun Yat-Sen University, Guangzhou, Guangdong, China.
Weian ChenDepartment of Nuclear Medicine, The First Affiliated Hospital, Sun Yat-Sen University, Guangzhou, Guangdong, China.
Jianbo LiuDepartment of Nuclear Medicine, The First Affiliated Hospital, Sun Yat-Sen University, Guangzhou, Guangdong, China.
Xiangdong XuDepartment of Breast and Thyroid Surgery, The First Affiliated Hospital, Sun Yat-Sen University, Guangzhou, Guangdong, China. xuxdong2@mail.sysu.edu.cn.
Zhihao ZhaDepartment of Nuclear Medicine, The First Affiliated Hospital, Sun Yat-Sen University, Guangzhou, Guangdong, China. zhazhh@mail.sysu.edu.cn.
Xiangsong ZhangDepartment of Nuclear Medicine, The First Affiliated Hospital, Sun Yat-Sen University, Guangzhou, Guangdong, China. zhxiangs@mail.sysu.edu.cn.ORCID http://orcid.org/0000-0002-1730-9923

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesTo evaluate the diagnostic performance of ¹⁸F-fluoro-L-ascorbic acid ([¹⁸F]FAA) positron emission tomography-computed tomography (PET/CT) in detecting metastatic differentiated thyroid cancer (DTC) and compare it with ¹⁸F-fluorodeoxyglucose ([¹⁸F]FDG) PET/CT. MATERIALS AND

methodsData were retrospectively collected from patients who were clinically suspected or diagnosed with postoperative metastatic DTC between September 2023 and May 2024. Quantification was performed using the maximum standardized uptake value (SUVmax) and target-to-background ratio (TBR). Histopathological outcomes and clinical follow-up served as the reference standard for final diagnosis. Diagnostic accuracy was compared using McNemar's test, and tracer uptake was analyzed via the Wilcoxon signed-rank test.

resultsA total of 85 participants (median age, 51 years; IQR, 38-61 years; 45 women) were evaluated. For cervical lymph nodes (LNs), [¹⁸F]FAA showed superior sensitivity (88% vs. 67%), accuracy (82% vs. 69%), and negative predictive value (78% vs. 57%) (all p < 0.001), with comparable specificity (72% vs. 74%, p = 0.64) and positive predictive value (84% vs. 81%; p = 0.44) than [

conclusion[ KEY POINTS: Question Is 6-Deoxy-6-[

Indexed as

Ascorbic AcidFluorodeoxyglucose F18Positron Emission Tomography Computed TomographyThyroid NeoplasmsAdultFemaleHumansLymphatic MetastasisMaleMiddle AgedRadiopharmaceuticalsRetrospective StudiesSensitivity and SpecificityAscorbic AcidFluorodeoxyglucose F18Radiopharmaceuticals6-Deoxy-6-fluoro-L-ascorbic acidFluorodeoxyglucose F18Neoplasm metastasisPositron-emission tomographyThyroid neoplasms

Identifiers

PMID41176553

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.