Evidence map›Paper›PMID 41176538›Full record

ArticleActa pharmacologica Sinica2026

Targeting the 5-HT

Min-Chun Jiang, Huan-Yu Ding, Chak Kwong Cheng, Dong-Qin Cai, Hai-Xia Guan, Jian Kuang, Ronald Ching Wan Ma, Yin Xia, Xiao-Qiang Yao, Li Wang and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Acta pharmacologica Sinica, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Min-Chun Jiang *Department of Endocrinology, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou, 510080, China.
Huan-Yu Ding *School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong, 999077, China.
Chak Kwong ChengDepartment of Biomedical Sciences, College of Biomedicine, City University of Hong Kong, Hong Kong, 999077, China.
Dong-Qin CaiSchool of Medicine, South China University of Technology, Guangzhou, 510006, China.
Hai-Xia GuanDepartment of Endocrinology, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou, 510080, China.
Jian KuangDepartment of Endocrinology, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou, 510080, China.
Ronald Ching Wan MaDepartment of Medicine and Therapeutics and Li Ka Shing Institute of Health Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong, 999077, China.
Yin XiaSchool of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong, 999077, China.
Xiao-Qiang YaoSchool of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong, 999077, China.
Li WangDepartment of Biomedical Sciences, College of Biomedicine, City University of Hong Kong, Hong Kong, 999077, China.
Yu HuangDepartment of Biomedical Sciences, College of Biomedicine, City University of Hong Kong, Hong Kong, 999077, China. yu.huang@cityu.edu.hk.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Atherosclerosis preferentially develops at arterial bifurcations where the endothelial cells are constantly exposed to disturbed flow, and sustained oscillatory shear stress (OSS) triggers endothelial inflammation. The mechanosensitive transcriptional coactivator YAP plays a critical role in disturbed flow-induced endothelial inflammation. Our recent studies show that disturbed flow upregulates the expression of the mechanosensor 5-HT

Indexed as

Adaptor Proteins, Signal TransducingAtherosclerosisReceptor, Serotonin, 5-HT1BTranscription FactorsAnimalsApolipoproteins ECell Cycle ProteinsCells, CulturedEndothelial CellsFeedback, PhysiologicalHumansMaleMiceMice, Inbred C57BLMice, KnockoutStress, MechanicalAdaptor Proteins, Signal TransducingApolipoproteins ECell Cycle ProteinsReceptor, Serotonin, 5-HT1BTranscription FactorsYAP1 protein, humanYap1 protein, mouseYAP-Signaling Proteins5-HT1B-YAP positive feedback loopatherosclerosisdisturbed flowendothelial cellsinflammation

Identifiers

PMID41176538
PMCPMC12932742

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.