Evidence map›Paper›PMID 41176522›Full record

ArticleAngiogenesis2025

Multidirectional interstitial flow promotes microvascular network formation: insights from a square chip-based platform.

Qihang Yang, Yuening He, Shuo Wang, Zengting Li, Jiaxuan Wang, Zehao Sun, Wenbo Yang, Xiang Zhong, Bo Peng, Zaozao Chen and 3 more

Abstract read
PubMed Publisher
In one paragraph

Article in Angiogenesis, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Qihang Yang *MOE Key Laboratory for Biomedical Photonics, Wuhan National Laboratory for Optoelectronics - Advanced Biomedical Imaging Facility, Huazhong University of Science and Technology, Wuhan, 430074, Hubei, China.
Yuening He *MOE Key Laboratory for Biomedical Photonics, Wuhan National Laboratory for Optoelectronics - Advanced Biomedical Imaging Facility, Huazhong University of Science and Technology, Wuhan, 430074, Hubei, China.
Shuo WangMOE Key Laboratory for Biomedical Photonics, Wuhan National Laboratory for Optoelectronics - Advanced Biomedical Imaging Facility, Huazhong University of Science and Technology, Wuhan, 430074, Hubei, China.
Zengting LiMOE Key Laboratory for Biomedical Photonics, Wuhan National Laboratory for Optoelectronics - Advanced Biomedical Imaging Facility, Huazhong University of Science and Technology, Wuhan, 430074, Hubei, China.
Jiaxuan WangMOE Key Laboratory for Biomedical Photonics, Wuhan National Laboratory for Optoelectronics - Advanced Biomedical Imaging Facility, Huazhong University of Science and Technology, Wuhan, 430074, Hubei, China.
Zehao SunMOE Key Laboratory for Biomedical Photonics, Wuhan National Laboratory for Optoelectronics - Advanced Biomedical Imaging Facility, Huazhong University of Science and Technology, Wuhan, 430074, Hubei, China.
Wenbo YangMOE Key Laboratory for Biomedical Photonics, Wuhan National Laboratory for Optoelectronics - Advanced Biomedical Imaging Facility, Huazhong University of Science and Technology, Wuhan, 430074, Hubei, China.
Xiang ZhongMOE Key Laboratory for Biomedical Photonics, Wuhan National Laboratory for Optoelectronics - Advanced Biomedical Imaging Facility, Huazhong University of Science and Technology, Wuhan, 430074, Hubei, China.
Bo PengFrontiers Science Center for Flexible Electronics, Xi'an Institute of Flexible Electronics (IFE) and Xi'an Institute of Biomedical Materials & Engineering, Northwestern Polytechnical University, Xi'an, 710072, Shanxi, China.
Zaozao ChenDigital Medical Engineering, School of Biological Science and Medical Engineering, Southeast University, Nanjing, 210096, Jiangsu, China.
Zhongze GuDigital Medical Engineering, School of Biological Science and Medical Engineering, Southeast University, Nanjing, 210096, Jiangsu, China.
Dan ZhuMOE Key Laboratory for Biomedical Photonics, Wuhan National Laboratory for Optoelectronics - Advanced Biomedical Imaging Facility, Huazhong University of Science and Technology, Wuhan, 430074, Hubei, China. dawnzh@mail.hust.edu.cn.
Tingting YuMOE Key Laboratory for Biomedical Photonics, Wuhan National Laboratory for Optoelectronics - Advanced Biomedical Imaging Facility, Huazhong University of Science and Technology, Wuhan, 430074, Hubei, China. yutingting@hust.edu.cn.

Funding

the Fundamental Research Funds for the Central Universities HUST: 2025JYCXJJ020the Open Competition Project of Wuhan East Lake High-tech Development Zone 2023KJB213the Open Project Program of Wuhan National Laboratory for Optoelectronics 2022WNLOKF009
6 · The paper itself

Abstract

Microvascular network formation is governed by a variety of factors, with interstitial flow (IF) playing a pivotal role. However, the impact of multidirectional IF (MDIF) on microvascular network development remains insufficiently explored. In this study, we developed a platform consisting of a Square chip capable of generating MDIF and a deep learning-based Vasculature-on-a-Chip Analysis Tool (VoCAT) for high-efficient analysis of vascular morphology on the chip. Using this platform, we demonstrated that microvascular networks formed on the Square chip exhibited intricate structural features with enhanced functionality. We also demonstrated its utility in modeling a tumor microenvironment with complex microvascular networks and observed enhanced tumor cell migration. This study provides the first evidence that MDIF promotes microvascular network formation, offering new perspectives for advanced in vitro vascular and disease research.

Indexed as

Lab-On-A-Chip DevicesMicrovesselsAnimalsCell MovementHumansTumor MicroenvironmentDeep learningInterstitial flowMicrovascular networkMicrovascular organ-on-a-chip

Identifiers

PMID41176522

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.