Evidence map›Paper›PMID 41176515›Full record

ArticleAnnals of surgical oncology2026

The Prognostic Impact of C-Reactive Protein-Albumin-Lymphocyte Index (Cally Index) in Patients with Surgically Resected Non-Small-Cell Lung Cancer.

Kazuhiro Mizota, Fumihiko Kinoshita, Bassi Giacomo, Takayuki Tokunaga, Asato Hashinokuchi, Kyoto Matsudo, Taichi Nagano, Keisuke Kosai, Takaki Akamine, Takatoshi Fujishita and 5 more

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Article in Annals of surgical oncology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 1 synthesis or guideline pooled it.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Kazuhiro MizotaDepartment of Surgery and Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.
Fumihiko KinoshitaDepartment of Surgery and Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan. kinoshita2315@gmail.com.
Bassi GiacomoDepartment of Surgery and Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.
Takayuki TokunagaDepartment of Surgery and Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.
Asato HashinokuchiDepartment of Surgery and Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.
Kyoto MatsudoDepartment of Surgery and Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.
Taichi NaganoDepartment of Surgery and Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.
Keisuke KosaiDepartment of Thoracic Oncology, National Hospital Organization Kyushu Cancer Center, Fukuoka, Japan.
Takaki AkamineDepartment of Surgery and Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.
Takatoshi FujishitaDepartment of Thoracic Oncology, National Hospital Organization Kyushu Cancer Center, Fukuoka, Japan.
Shinichiro ShimamatsuDepartment of Thoracic Oncology, National Hospital Organization Kyushu Cancer Center, Fukuoka, Japan.
Mikihiro KohnoDepartment of Surgery and Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.
Masafumi YamaguchiDepartment of Thoracic Oncology, National Hospital Organization Kyushu Cancer Center, Fukuoka, Japan.
Tomoyoshi TakenakaDepartment of Surgery and Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.
Tomoharu YoshizumiDepartment of Surgery and Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe C-reactive protein (CRP)-albumin-lymphocyte (CALLY) index is a new scoring system that evaluates both inflammatory and nutritional status. We aimed to investigate the clinical significance of the CALLY index as a prognostic biomarker in resected non-small-cell lung cancer (NSCLC).

methodsWe classified 581 and 634 patients with NSCLC clinical stages I-IIIA who underwent surgery between 2013 and 2018 as the discovery and validation cohorts, respectively. The CALLY index was calculated using the following formula: (serum albumin × lymphocytes) / (CRP × 10

resultsIn the discovery cohort, 329 (56.6%) and 252 (43.3%) patients were classified as CALLY-high and CALLY-low, respectively; in the validation cohort, 353 (55.7%) and 281 (44.3%) patients were classified as CALLY-high and CALLY-low, respectively. In both cohorts, the CALLY-low group was associated with older age, male sex, smoking, and advanced cancer stage. Multivariable analysis in both cohorts showed that CALLY-low was an independent poor prognostic factor for recurrence-free survival: hazard ratio (HR) 1.4; 95% confidence interval (CI) 1.02-2.02 and HR 1.4; 95% CI 1.02-1.87, respectively. It was also an independent poor prognostic factor for overall survival: HR 2.1; 95% CI 1.31-3.25 and HR 1.6; 95% CI 1.11-2.29, respectively.

conclusionThe CALLY index is a useful prognostic predictor in resected NSCLC.

Indexed as

Adenocarcinoma of LungBiomarkers, TumorCarcinoma, Non-Small-Cell LungCarcinoma, Squamous CellC-Reactive ProteinLung NeoplasmsLymphocytesSerum AlbuminAdenocarcinomaAgedFemaleFollow-Up StudiesHumansMaleMiddle AgedNeoplasm StagingBiomarkers, TumorC-Reactive ProteinSerum AlbuminC-reactive protein albumin-lymphocyte index (CALLY index),Non-small cell lung cancer,Prognostic factor,Surgery

Identifiers

PMID41176515

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.