Evidence map›Paper›PMID 41176511›Full record

ArticleBasic research in cardiology2025

The role of NO, H

Kostiantyn Drachuk, Yoshinori Nishijima, Aravind Parthasarathy, Yangjing Xie, Sneha Nagavally, Aprill Dawson, David D Gutterman, David X Zhang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Basic research in cardiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Kostiantyn DrachukDepartment of Medicine, Cardiovascular Center, Medical College of Wisconsin, Milwaukee, WI, 53226, USA.
Yoshinori NishijimaDepartment of Medicine, Cardiovascular Center, Medical College of Wisconsin, Milwaukee, WI, 53226, USA.
Aravind ParthasarathyDepartment of Medicine, Cardiovascular Center, Medical College of Wisconsin, Milwaukee, WI, 53226, USA.
Yangjing XieDepartment of Medicine, Cardiovascular Center, Medical College of Wisconsin, Milwaukee, WI, 53226, USA.
Sneha NagavallyCenter for Advancing Population Science, Medical College of Wisconsin, Milwaukee, WI, 53226, USA.
Aprill DawsonCenter for Advancing Population Science, Medical College of Wisconsin, Milwaukee, WI, 53226, USA.
David D GuttermanDepartment of Medicine, Cardiovascular Center, Medical College of Wisconsin, Milwaukee, WI, 53226, USA.
David X ZhangDepartment of Medicine, Cardiovascular Center, Medical College of Wisconsin, Milwaukee, WI, 53226, USA. xfzhang@mcw.edu.

Funding

TRP Channels In The Regulation of Vascular ToneR01HL096647 · NHLBI · MEDICAL COLLEGE OF WISCONSIN · PI ZHANG, DAVID X. · 2011 to 2024
$5.5M
Molecular mechanisms of polymodal TRP channels in regulation of microvascular endothelial functionR01HL181985 · NHLBI · MEDICAL COLLEGE OF WISCONSIN · PI David X. Zhang · 2025 to 2026
$1.4M
NHLBI NIH HHS R01 HL096647NHLBI NIH HHS R01HL096647NHLBI NIH HHS R01 HL181985NHLBI NIH HHS R01HL181985
6 · The paper itself

Abstract

This study defines the mechanisms of vasodilation to acetylcholine (ACh) in arterioles from patients with and without coronary artery disease (CAD). Human adipose arterioles (HAA) dissected from discarded surgical samples were cannulated and pressurized at 60 mmHg for measurement of diameter changes by videomicroscopy. No difference in baseline dose response to ACh was observed between non-CAD and CAD patients. L-NAME, NO synthase inhibitor, reduced dilation in both groups but to a greater extent in non-CAD. Peg-CAT, H

Indexed as

AcetylcholineCoronary Artery DiseaseHydrogen PeroxideNitric OxideVasodilationVasodilator AgentsAgedArteriolesFemaleHumansMaleMiddle AgedNADPH Oxidase 2NADPH Oxidase 4NADPH OxidasesNitric Oxide Synthase Type IIIAcetylcholineCYBB protein, humanHydrogen PeroxideNADPH Oxidase 2NADPH Oxidase 4NADPH OxidasesNitric OxideNitric Oxide Synthase Type IIINOX4 protein, humanVasodilator AgentsAcetylcholineCoronary artery diseaseEndothelium-dependent vasodilationNitric oxide

Identifiers

PMID41176511
PMCPMC13046465

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.