Evidence map›Paper›PMID 41176235›Full record

ArticleBioorganic & medicinal chemistry letters2026

Hydantion indolinones as AANAT inhibitors.

Nicole Wandrey, Jake Boley, Dirce Gómez-Galicia, Mackinzi Hill, Mason Bach, Sidney Gawrych, Mackenzie Hagemeister, Philip A Cole, Michael A Moxley, Allen A Thomas

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Bioorganic & medicinal chemistry letters, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Nicole WandreyDepartment of Chemistry, University of Nebraska at Kearney, Kearney, NE 69949, USA.
Jake BoleyDepartment of Chemistry, University of Nebraska at Kearney, Kearney, NE 69949, USA.
Dirce Gómez-GaliciaDepartment of Chemistry, University of Nebraska at Kearney, Kearney, NE 69949, USA.
Mackinzi HillDepartment of Chemistry, University of Nebraska at Kearney, Kearney, NE 69949, USA.
Mason BachDepartment of Chemistry, University of Nebraska at Kearney, Kearney, NE 69949, USA.
Sidney GawrychDepartment of Chemistry, University of Nebraska at Kearney, Kearney, NE 69949, USA.
Mackenzie HagemeisterDepartment of Chemistry, University of Nebraska at Kearney, Kearney, NE 69949, USA.
Philip A ColeDivision of Genetics, Department of Medicine, Brigham and Women's Hospital; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115, USA.
Michael A MoxleyDepartment of Chemistry, University of Nebraska at Kearney, Kearney, NE 69949, USA.
Allen A ThomasDepartment of Chemistry, University of Nebraska at Kearney, Kearney, NE 69949, USA. Electronic address: thomasaa@unk.edu.

Funding

UNMC Structural Biology CoreP20GM103427 · NIGMS · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI PAUL L SORGEN · 2012 to 2026
$59.2M
Chemical Approaches to Understanding Reversible Lysine ModificationsR35GM149229 · NIGMS · BRIGHAM AND WOMEN'S HOSPITAL · PI PHILIP A COLE · 2023 to 2026
$1.9M
Serotonin N-Acetyl-Transferase Inhibitors for Circadian Rhythm DisordersR15HL165700 · NHLBI · UNIVERSITY OF NEBRASKA KEARNEY · PI THOMAS, ALLEN · 2022 to 2022
$395k
NHLBI NIH HHS R15 HL165700NIGMS NIH HHS P20 GM103427NIGMS NIH HHS R35 GM149229
6 · The paper itself

Abstract

Arylalkylamine N-acetyltransferase (AANAT) is a key enzyme in melatonin biosynthesis and a regulator of circadian rhythm, with potential relevance to mood disorders such as seasonal affective disorder (SAD). We report a series of hydantoin indolinone-based AANAT inhibitors, developed as more stable alternatives to a previously reported rhodanine scaffold. Guided by docking studies and prior structure-activity data, we modified four regions of the molecule to improve potency. Substitution at the 5-position of the indolinone ring led to marked increases in activity, with compound 5g (bearing a CH

Indexed as

Arylalkylamine N-AcetyltransferaseEnzyme InhibitorsIndolesHumansMolecular Docking SimulationMolecular StructureStructure-Activity RelationshipArylalkylamine N-AcetyltransferaseEnzyme InhibitorsIndolesAcetyl transferaseCircadian rhythmMelatoninMood disorders

Identifiers

PMID41176235
PMCPMC12610919

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.