Evidence map›Paper›PMID 41175871›Full record

ArticleNeuron2025

G-protein-coupled receptor ADGRG1 drives a protective microglial state in Alzheimer's disease through MYC activation.

Beika Zhu, Andi Wangzhou, Diankun Yu, Tao Li, Rachael Schmidt, Stacy L De Florencio, Lauren Chao, Alicia L Thurber, Minqi Zhou, Zeina Msheik and 8 more

Abstract readPublished Erratum
PubMed Full text at PMC Publisher
In one paragraph

Article in Neuron, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

18 authors.

Beika Zhu
Andi Wangzhou
Diankun Yu
Tao Li
Rachael Schmidt
Stacy L De Florencio
Lauren Chao
Alicia L Thurber
Minqi Zhou
Zeina Msheik
Yonatan Perez
Lea T Grinberg
Salvatore Spina
Richard M Ransohoff
Arnold R Kriegstein
William W Seeley
Tomasz Nowakowski
Xianhua Piao

Funding

Research Education ComponentP30AG062422 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Gil Dan Rabinovici · 2019 to 2026
$36.9M
PrPSc SPECIFIC INTERACTION WITH NOVEL PrP-Fc FUSION PROTEINSP50AG023501 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI MILLER, BRUCE L · 2004 to 2018
$27.1M
Adhesion G Protein-Coupled Receptors in CNS Development and RegenerationR01NS094164 · NINDS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI PIAO, XIANHUA · 2015 to 2025
$4.5M
Glial Mechanisms Of Developmental Synapse RefinementR01NS108446 · NINDS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI PIAO, XIANHUA · 2018 to 2022
$2.9M
GPCR-dependent microglial function in Alzheimer's diseaseK99AG081694 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI ZHU, BEIKA · 2024 to 2025
$230k
NIA NIH HHS K99 AG081694NIA NIH HHS P30 AG062422NIA NIH HHS P50 AG023501NINDS NIH HHS R01 NS094164NINDS NIH HHS R01 NS108446
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Identifiers

PMID41175871
PMCPMC13008243

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.