Evidence map›Paper›PMID 41175503›Full record

ArticleMolecular pharmacology2025

Electrophysiological characterization of the state-dependent inhibition of Kv7.1 and I

Daniel Sastre, Efthimios Kyriakis, Julia Schauer, Magnus Chan, Ying Dou, Jodene Eldstrom, David Fedida

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular pharmacology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Daniel SastreDepartment of Anesthesiology, Pharmacology and Therapeutics, University of British Columbia, Vancouver, Canada.
Efthimios KyriakisDepartment of Anesthesiology, Pharmacology and Therapeutics, University of British Columbia, Vancouver, Canada.
Julia SchauerDepartment of Anesthesiology, Pharmacology and Therapeutics, University of British Columbia, Vancouver, Canada.
Magnus ChanDepartment of Anesthesiology, Pharmacology and Therapeutics, University of British Columbia, Vancouver, Canada.
Ying DouDepartment of Anesthesiology, Pharmacology and Therapeutics, University of British Columbia, Vancouver, Canada.
Jodene EldstromDepartment of Anesthesiology, Pharmacology and Therapeutics, University of British Columbia, Vancouver, Canada.
David FedidaDepartment of Anesthesiology, Pharmacology and Therapeutics, University of British Columbia, Vancouver, Canada. Electronic address: David.fedida@ubc.ca.

Funding

GENE THERAPY FOR HEPATITIS C INFECTION--CHRONIC INFECTIOUS DISEASE MODELZ01CL002077 · CLC · CLINICAL CENTER · PI SHIH, J W · 1996 to 1998
–
Intramural NIH HHS Z01 CL002077
6 · The paper itself

Abstract

In cardiomyocytes, Kv7.1 associates with the regulatory subunit KCNE1 to generate the delayed rectifier potassium current I

Indexed as

KCNQ1 Potassium ChannelPotassium Channel BlockersPotassium Channels, Voltage-GatedPyridinesAction PotentialsAnimalsHEK293 CellsHumansMyocytes, CardiacPatch-Clamp TechniquesKCNE1 protein, humanKCNQ1 Potassium ChannelKCNQ1 protein, humanPotassium Channel BlockersPotassium Channels, Voltage-GatedPyridinesCardiac physiologyCardiac repolarizationIon channel pharmacologyKv7.1 (KCNQ1)Short QT syndromeUCL2077

Identifiers

PMID41175503
PMCPMC12799529

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.