ArticleThe Journal of international medical research2025
Assessment of relationships between frailty and diabetes: A two-sample Mendelian randomization study.
Article in The Journal of international medical research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
1 citing paper in PubMed, 1 synthesis or guideline pooled it.
- Evaluation of the Risk Prediction Model for Frailty in Diabetic Patients: A Systematic Review and Meta-Analysis.Journal of diabetes research · 2026Pooled it
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
ObjectivesObservational studies have suggested a unidirectional association between frailty and diabetes; however, their causal relationship remains unclear. This study aimed to investigate the bidirectional causal associations between frailty and diabetes to provide more definitive evidence.MethodsWe conducted a two-sample Mendelian randomization study using genome-wide association study data to examine the bidirectional causal relationship between frailty-measured by the frailty index and Fried Frailty Phenotype-and diabetes, including type 2 diabetes mellitus, type 1 diabetes mellitus, fasting glucose, fasting insulin, and glycated hemoglobin. The inverse variance-weighted method was used for the primary analysis. Pleiotropy was assessed using the Mendelian randomization-Egger intercept and Mendelian randomization-PRESSO methods. Sensitivity analyses were performed using the leave-one-out approach and Cochran's Q test to ensure robustness of the findings.ResultsType 2 diabetes mellitus was significantly associated with both the frailty index (β = 0.029, 95% confidence interval: 0.014-0.043, p
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