Trial reportThe Journal of international medical research2025
Comparison of the effect of preoperative glycopyrrolate and penehyclidine hydrochloride on postoperative nausea and vomiting in patients undergoing laparoscopic cholecystectomy: A randomized controlled trial.
Trial report in The Journal of international medical research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
ObjectiveTo investigate the effect of preoperative glycopyrrolate and penehyclidine hydrochloride on postoperative nausea and vomiting in patients undergoing laparoscopic cholecystectomy.MethodsThis prospective, randomized, double-blind, controlled trial enrolled 120 patients who underwent laparoscopic cholecystectomy. Patients were randomly assigned to the glycopyrrolate group, penehyclidine hydrochloride group, or normal saline group. Postoperative nausea and vomiting, hemodynamic parameters, anesthetic consumption, duration of postanesthesia care unit stay, and other perioperative adverse events were recorded.ResultsThe incidence of postoperative nausea and vomiting within 1 h in the penehyclidine hydrochloride group was significantly lower than that in the normal saline and glycopyrrolate groups. The heart rate at immediately prior to anesthesia induction, 1 min after endotracheal intubation, the start of surgery, 2 min after pneumoperitoneum, and cholecyst dissection and mean arterial pressure at 1 min after endotracheal intubation and the start of surgery in the normal saline group were significantly lower than those in the glycopyrrolate group. The heart rate at immediately prior to anesthesia induction, 1 min after endotracheal intubation, the start of surgery, and 2 min after pneumoperitoneum and mean arterial pressure at 1 min after endotracheal intubation in the penehyclidine hydrochloride group were markedly lower than those in the glycopyrrolate group. The incidence of bradycardia in the normal saline and penehyclidine hydrochloride groups was significantly higher than that in the glycopyrrolate group.ConclusionsPenehyclidine hydrochloride is more effective than glycopyrrolate in preventing postoperative nausea and vomiting in patients undergoing laparoscopic cholecystectomy, particularly in the early postoperative period.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.