Evidence map›Paper›PMID 41175312›Full record

ArticleGeroScience2026

Gut microbiome signatures predict cognitive impairment in older cancer survivors.

Brandi C Miller, Jayden A Haggler, Diptaraj S Chaudhari, Rohit Shukla, Vivek Kumar, Sidharth P Mishra, Michal M Masternak, Peter Holland, Corinne Labyak, Adam Golden and 10 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in GeroScience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Review
  3. Review
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors.

Brandi C MillerUSF Center for Microbiome Research, Microbiomes Institute, University of South Florida Morsani College of Medicine, Tampa, FL, USA.
Jayden A HagglerUSF Center for Microbiome Research, Microbiomes Institute, University of South Florida Morsani College of Medicine, Tampa, FL, USA.
Diptaraj S ChaudhariUSF Center for Microbiome Research, Microbiomes Institute, University of South Florida Morsani College of Medicine, Tampa, FL, USA.
Rohit ShuklaUSF Center for Microbiome Research, Microbiomes Institute, University of South Florida Morsani College of Medicine, Tampa, FL, USA.
Vivek KumarUSF Center for Microbiome Research, Microbiomes Institute, University of South Florida Morsani College of Medicine, Tampa, FL, USA.
Sidharth P MishraUSF Center for Microbiome Research, Microbiomes Institute, University of South Florida Morsani College of Medicine, Tampa, FL, USA.
Michal M MasternakBurnett School of Biomedical Sciences, College of Medicine, University of Central Florida, Orlando, FL, USA.
Peter HollandDepartment of Neuroscience, Schmidt College of Medicine, Florida Atlantic University, Boca Raton, FL, USA.
Corinne LabyakDepartment of Nutrition and Dietetics, University of North Florida, Jacksonville, FL, USA.
Adam GoldenDepartment of Internal Medicine, University of Central Florida College of Medicine, Orlando, FL, USA.
Mariana DangioloDepartment of Internal Medicine, University of Central Florida College of Medicine, Orlando, FL, USA.
Andrea Y ArikawaDepartment of Nutrition and Dietetics, University of North Florida, Jacksonville, FL, USA.
Judyta KociolekClinical Research Unit, Division of Research, Florida Atlantic University, Boca Raton, FL, USA.
Amoy FraserDepartment of Internal Medicine, University of Central Florida College of Medicine, Orlando, FL, USA.
Cynthia WilliamsSchool of Global Health Management and Informatics, University of Central Florida, Orlando, FL, USA.
Marc AgroninBehavioral Health, MIND Institute, Miami Jewish Health, Miami, FL, USA.
Mariolga AymatBehavioral Health, MIND Institute, Miami Jewish Health, Miami, FL, USA.
Warren PledgerTampa General Hospital Cancer Institute, Tampa, FL, USA.
Hariom YadavUSF Center for Microbiome Research, Microbiomes Institute, University of South Florida Morsani College of Medicine, Tampa, FL, USA.
Shalini JainUSF Center for Microbiome Research, Microbiomes Institute, University of South Florida Morsani College of Medicine, Tampa, FL, USA. jains10@usf.edu.ORCID http://orcid.org/0000-0001-5200-5928

Funding

Florida Department of Health 22A17
6 · The paper itself

Abstract

Cancer treatments are improving, and the population of cancer survivors is steadily increasing. However, many survivors experience long-term side effects, including chemobrain and other age-related geriatric disorders like cognitive impairment (CI), severely impacting their quality of life. Emerging studies suggest that the gut microbiome plays a central role in cognitive health. However, the long-term effects of cancer treatments on the microbiome, and how these changes impact cognitive health in survivors, remain largely unknown. Shotgun metagenomic data from 150 older adults (≥ 60 years old, including 49 cancer survivors and 101 controls) from the Microbiome in Aging Gut and Brain (MiaGB) consortium revealed that Tyzzerella, Eggerthella lenta, and Bacteroides vulgatus were specific markers of the cancer survivor gut and could differentiate cancer survivorship in this cohort. Microbiome signatures were distinct in cancer survivors with CI compared to those without and differed from those seen in non-cancer individuals with CI. Bacterial taxa including Streptococcus thermophilus and Firmicutes bacterium CAG 114 were significantly reduced in cancer survivors and strongly associated with CI. Importantly, metabolic pathway analysis revealed that microbial neurotransmitter synthesis was significantly depleted in the gut of cancer survivors, suggesting a mechanistic link to CI. Our results suggest that microbiome signatures predict cancer survivorship and the risk of CI in older adults, potentially by depleting neurotransmitter synthesis in the gut. These findings aid in establishing the role of the microbiome in predicting cancer survivorship and CI risk, which is valuable in the development of novel therapies to support the growing population of cancer survivors.

Indexed as

Cancer SurvivorsCognitive DysfunctionGastrointestinal MicrobiomeNeoplasmsAgedFemaleHumansMaleMiddle AgedAgingBrainCancerCognitionGutMicrobiome

Identifiers

PMID41175312
PMCPMC13575041

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.