Evidence map›Paper›PMID 41175278›Full record

ArticleJournal of nephrology2025

Green haemodialysis: comparison of dialysis bags versus fresenius granumix at the AOU Policlinico di Modena, Italy.

James Larkin, Gaetano Alfano, Giulia Ligabue, Rodrigo Martínez Cadenas, Karin G F Gerritsen, Abass Fehintola, Gabriele Donati, Brett Duane

Abstract readComparative Study
In one paragraph

Article in Journal of nephrology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

James Larkin *School of Dental, Child and Public Health, Trinity College Dublin, Dublin, Ireland. larkinj4@tcd.ie.ORCID 0009-0007-5152-2414
Gaetano Alfano *Department CHIMOMO, University of Modena and Reggio Emilia, Modena, Italy.
Giulia LigabueDepartment CHIMOMO, University of Modena and Reggio Emilia, Modena, Italy.
Rodrigo Martínez CadenasUniversidad Autonoma de Madrid, Madrid, Spain.
Karin G F GerritsenUniversity Medical Centre Utrecht, Utrecht, Netherlands.
Abass FehintolaSchool of Dental, Child and Public Health, Trinity College Dublin, Dublin, Ireland.
Gabriele DonatiDepartment CHIMOMO, University of Modena and Reggio Emilia, Modena, Italy.
Brett DuaneSchool of Dental, Child and Public Health, Trinity College Dublin, Dublin, Ireland.

Funding

HORIZON EUROPE European Innovation Council 101137054
6 · The paper itself

Abstract

backgroundHaemodialysis (HD) has a significant environmental footprint due to its high resource consumption  and waste generation. A key component is dialysate production, which typically involves mixing water, bicarbonate, and a single-use acid concentrate bag for each session. An alternative method is the central delivery of acid concentrate, prepared on-site using dry powder formulations. This study compares the environmental impact of these two delivery systems, focusing on waste reduction, elimination of single-use plastic, and decreased transport-related emissions.

methodsA detailed life cycle assessment (LCA) was carried out using OpenLCA and the Ecoinvent v3.1 database to compare the traditional acid concentrate bag system with the central delivery system (Granumix, Fresenius, Germany). Data on material inputs, energy use, waste generation, and transportation were collected. Flow diagrams captured the full life cycle of each method, and various environmental indicators were analysed, including climate change, acidification, and ecotoxicity.

resultsThe Granumix system demonstrated considerably lower environmental impact than traditional bag use. It reduced climate change potential by 30% (CO₂-equivalent) and freshwater ecotoxicity by 15%. Additional benefits were observed in acidification, resource use, and overall emissions, indicating the system's broader environmental advantages.

conclusionsThe central delivery of acid concentrate using the Granumix system is a more sustainable option for HD, significantly reducing environmental burdens across several categories. These findings underscore the value of adopting innovative delivery models to make essential healthcare treatments more environmentally sustainable.

Indexed as

Renal DialysisClimate ChangeHumansItalyAcid concentrate bagsCarbon footprintDialysateEnd stage kidney diseaseEnvironmentFresenius granumix plus systemHaemodialysisLife cycle assessmentResource consumptionSustainabilityWaste generationWater use

Identifiers

PMID41175278
PMCPMC12712103

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.