Evidence map›Paper›PMID 41175239›Full record

ArticleMikrochimica acta2025

Dual-emissive silicon quantum dots as a ratiometric fluorogenic probe for alkaline phosphatase activity.

Yijun You, Na Li, Xin Gao, Xupeng Zhang, Xiangnan Zhang, Bin Wang, Minmin Zhang, Yulong Chen, Lingling Shui

Abstract read
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In one paragraph

Article in Mikrochimica acta, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

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4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Yijun YouGuangdong Provincial Key Laboratory of Nanophotonic Functional Materials and Devices, School of Optoelectronic Science and Engineering, South China Normal University, Guangzhou, 510006, P.R. China.
Na LiGuangdong Provincial Key Laboratory of Nanophotonic Functional Materials and Devices, School of Optoelectronic Science and Engineering, South China Normal University, Guangzhou, 510006, P.R. China. dreamerlina@163.com.
Xin GaoChina Customs Science and Technology Research Center, Beijing, 100000, P.R. China.
Xupeng ZhangGuangdong Provincial Key Laboratory of Nanophotonic Functional Materials and Devices, School of Optoelectronic Science and Engineering, South China Normal University, Guangzhou, 510006, P.R. China.
Xiangnan ZhangSchool of Chemistry and Chemical Engineering, Yancheng Institute of Technology, Yancheng, 224051, Jiangsu, P.R. China. xnzhang@ycit.edu.cn.
Bin WangGuangdong Provincial Key Laboratory of Intelligent Port Security Inspection, Guangzhou, 510510, P.R. China.
Minmin ZhangGuangdong Provincial Key Laboratory of Nanophotonic Functional Materials and Devices, School of Optoelectronic Science and Engineering, South China Normal University, Guangzhou, 510006, P.R. China.
Yulong ChenGuangdong Provincial Key Laboratory of Nanophotonic Functional Materials and Devices, School of Optoelectronic Science and Engineering, South China Normal University, Guangzhou, 510006, P.R. China.
Lingling ShuiGuangdong Provincial Key Laboratory of Nanophotonic Functional Materials and Devices, School of Optoelectronic Science and Engineering, South China Normal University, Guangzhou, 510006, P.R. China. shuill@m.scnu.edu.cn.

Funding

Guangdong Provincial Science and Technology Project 2023A1111120030National Natural Science Foundation of China No. 22402062the Guangdong Basic and Applied Basic Research Foundation No. 2025A1515012964the Open Project of Guangdong Provincial Key Laboratory of Intelligent Port Security Inspection 2023B1212010011
6 · The paper itself

Abstract

Most fluorescent silicon quantum dots (SiQDs) emit at a single wavelength, which limits their use in ratiometric sensing. Here, we describe the hydrothermal synthesis of dual-emissive SiQDs that showed two distinct peaks at ~ 400 nm and ~ 510 nm under 330 nm excitation. The underlying photoluminescence mechanism was elucidated. Leveraging alkaline phosphatase (ALP)-catalyzed hydrolysis of 4-nitrophenylphosphate disodium salt hexahydrate (PNPP) to 4-nitrophenol (PNP), we developed a ratiometric fluorescence assay for ALP activity that exploits the inner-filter effect among SiQDs, PNPP, and PNP. The sensor delivered a linear signal over the range 1-60 U L

Indexed as

Alkaline PhosphataseFluorescent DyesQuantum DotsSiliconAnimalsBiosensing TechniquesHydrolysisLimit of DetectionNitrophenolsOrganophosphorus CompoundsSpectrometry, Fluorescence4-nitrophenolAlkaline PhosphataseFluorescent DyesNitrophenolsnitrophenylphosphateOrganophosphorus CompoundsSiliconAlkaline phosphataseDual-emissionsRatiometric fluorescenceSilicon quantum dots

Identifiers

PMID41175239

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.