ArticleAnalytical and bioanalytical chemistry2025
A bio-SPME-LC-MS/MS method for the quantitative determination of cannabinoids in plasma samples: analytical strategy for optimization of matrix modification.
Article in Analytical and bioanalytical chemistry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Cannabis sp. has been widely used for both medicinal and recreational purposes globally. Analyzing cannabinoids and their metabolites in human plasma samples is crucial for managing acute intoxications and for therapeutic monitoring in patients. This study describes the optimization and validation of an innovative, sensitive, simple, and environmentally friendly biocompatible solid-phase microextraction (bio-SPME) method using a hydrophilic-lipophilic balance (HLB)/polyacrylonitrile (PAN)-thin film for the quantification of cannabinoids (cannabidiol, tetrahydrocannabinol, and cannabinol) and their main metabolites (11-hydroxy-Δ9-tetrahydrocannabinol and 11-nor-9-carboxy-Δ9-tetrahydrocannabinol acid) in human plasma samples. Extraction efficiency was compared between two geometry SPME devices (e.g., thin film and fiber geometry), showing that the use of the thin film microextraction (TFME) device improved extraction performance. Matrix modification was optimized using a central composite design to determine the optimal combination of sample dilution, organic modifier addition, and salt usage. The most effective matrix modification was achieved with 380 µL of phosphate-buffered saline solution containing 0.015 mol L
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