Evidence map›Paper›PMID 41175185›Full record

ArticleAnnals of medicine2025

Association between Onodera's prognostic nutritional Index and ultrasound-measured muscle thickness in amyotrophic lateral sclerosis: a retrospective cross-sectional study.

Tianhua Yang, Ying Wang, Xinyi Yan, Yuxuan Qiu, Ting Lin, Jialei Luo, Jiahui Tong, Jiayi Mao, Yunyi Dai, Yuehui Yu and 2 more

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PubMed Full text at PMC Publisher
In one paragraph

Article in Annals of medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Tianhua YangThe Fourth School of Clinical Medicine, Zhejiang Chinese Medical University, Hangzhou First People's Hospital, Hangzhou, China.ORCID 0009-0000-9965-8379
Ying WangDepartment of Ultrasonography, Affiliated Hangzhou First People's Hospital, School of Medicine, Westlake University, Hangzhou, China.ORCID 0009-0009-2862-7036
Xinyi YanDivision of Health Sciences, Hangzhou Normal University, Hangzhou, China.ORCID 0009-0004-5657-7105
Yuxuan QiuDepartment of Ultrasonography, Affiliated Hangzhou First People's Hospital, School of Medicine, Westlake University, Hangzhou, China.ORCID 0000-0002-5467-6466
Ting LinThe Fourth School of Clinical Medicine, Zhejiang Chinese Medical University, Hangzhou First People's Hospital, Hangzhou, China.
Jialei LuoThe Fourth School of Clinical Medicine, Zhejiang Chinese Medical University, Hangzhou First People's Hospital, Hangzhou, China.ORCID 0009-0002-9462-9936
Jiahui TongDepartment of Ultrasonography, Affiliated Hangzhou First People's Hospital, School of Medicine, Westlake University, Hangzhou, China.
Jiayi MaoThe Fourth School of Clinical Medicine, Zhejiang Chinese Medical University, Hangzhou First People's Hospital, Hangzhou, China.
Yunyi DaiDivision of Health Sciences, Hangzhou Normal University, Hangzhou, China.
Yuehui YuDivision of Health Sciences, Hangzhou Normal University, Hangzhou, China.
Min ZhaoDepartment of Ultrasonography, Affiliated Hangzhou First People's Hospital, School of Medicine, Westlake University, Hangzhou, China.
Gaoyi YangDepartment of Ultrasonography, Affiliated Hangzhou First People's Hospital, School of Medicine, Westlake University, Hangzhou, China.ORCID 0000-0002-0759-3684

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundAmyotrophic lateral sclerosis (ALS) causes progressive muscle wasting. Ultrasound-measured thickness captures this loss. Nutritional status influences ALS prognosis, yet the link between Onodera's Prognostic Nutritional Index (OPNI) and muscle thickness is unclear.

objectiveTo assess whether OPNI correlates with thickness of the first dorsal interosseous (FDI), biceps brachii (BB) and masseter (MM) muscles, and to judge OPNI's utility as a practical nutrition marker in ALS.

methodsIn this retrospective study of 150 ALS patients, ultrasound quantified FDI, BB and MM thickness. Patients were stratified by OPNI quartile. Group differences were tested with ANOVA/Kruskal-Wallis. Multivariable generalized linear models, adjusting for age, sex, ALSFRS-R, King's stage, comorbidities and lifestyle factors, examined independent associations; restricted cubic splines probed non-linearity.

resultsMuscle thickness rose progressively across OPNI quartiles (

conclusionHigher OPNI independently predicts greater muscle thickness, indicating that better nutritional status parallels reduced muscle wasting in ALS. OPNI's low cost and rapid availability support its use to flag patients for early nutritional intervention.

Indexed as

Amyotrophic Lateral SclerosisMuscle, SkeletalNutritional StatusNutrition AssessmentAdultAgedCross-Sectional StudiesFemaleHumansMaleMiddle AgedPrognosisRetrospective StudiesUltrasonographyALSmuscle thicknessnutritionultrasound

Identifiers

PMID41175185
PMCPMC12581742

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.