Trial reportPain management2026
Dopamine agonist treatment normalizes neck motor dyscoordination and relieves pain in chronic tension-type headache and common whiplash. A pilot study.
Trial report in Pain management, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
3 authors.
Funding
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Abstract
aimsThis open-label non-placebo clinical trial was designed as an explorative test of a recent hypothesis suggesting a causative relation between neck muscle dyssynergia and pain in patients with chronic tension-type headache (TTH) and common whiplash (WL). A Dopamine agonist was used as test-treatment. The primary aim was to improve neck muscle dyssynergia and second to observe the effect on pain. PATIENTS &
methodsFifteen patients, comprising 8 tension-type headache and 7 common whiplash patients, all with significant neck muscle tenderness, were started on a standard Pramipexole treatment by 0.18 mg Pramipexole daily and increased by 0.18 mg weekly to 0.18 mg × 3 daily for maintenance. Weekly visits with measurements of head laser tracking (HLT) as indicator of neck muscle dyssynergia, total neck muscle tenderness score, and self-reported daily average headache and neck pain. Head laser tracking was compared to a control group of 8 untreated healthy persons.
resultsHLT normalized during treatment and clinical parameters of pain significantly improved.
conclusionThis result provides preliminary support of the hypothesis of a pathogenetic relation between the dyssynergic neck muscle innervation and pain in TTH and common WL. CLINICAL
trial registrationEudraCT 2021-003574-31.
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