Evidence map›Paper›PMID 41174999›Full record

Observational studyTherapeutic advances in respiratory disease

Unveiling the causes of bronchiectasis exacerbations: insights from a single-center study.

Martina Lo Casto, Carlo Chessari, Stefania Marino, Maria Fulvia Di Grado, Anna Isabella Memmo, Stefania Principe, Nicola Scichilone, Salvatore Battaglia

Abstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Therapeutic advances in respiratory disease. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Martina Lo CastoDivision of Respiratory Diseases, Department of Promozione della Salute, Materno Infantile, Medicina Interna e Specialistica di Eccellenza "G. D'Alessandro" - PROMISE - University of Palermo; Palermo, Italy.ORCID 0009-0000-6856-7319
Carlo ChessariDivision of Respiratory Diseases, Department of Promozione della Salute, Materno Infantile, Medicina Interna e Specialistica di Eccellenza "G. D'Alessandro" - PROMISE - University of Palermo; Palermo, Italy.
Stefania MarinoDivision of Respiratory Diseases, Department of Promozione della Salute, Materno Infantile, Medicina Interna e Specialistica di Eccellenza "G. D'Alessandro" - PROMISE - University of Palermo; Palermo, Italy.
Maria Fulvia Di GradoDivision of Respiratory Diseases, Department of Promozione della Salute, Materno Infantile, Medicina Interna e Specialistica di Eccellenza "G. D'Alessandro" - PROMISE - University of Palermo; Palermo, Italy.
Anna Isabella MemmoDivision of Respiratory Diseases, Department of Promozione della Salute, Materno Infantile, Medicina Interna e Specialistica di Eccellenza "G. D'Alessandro" - PROMISE - University of Palermo; Palermo, Italy.
Stefania PrincipeDivision of Respiratory Diseases; Department of Promozione della Salute, Materno Infantile, Medicina Interna e Specialistica di Eccellenza "G. D'Alessandro" - PROMISE - University of Palermo; Palermo, Italy.ORCID 0000-0001-7277-699X
Nicola ScichiloneDivision of Respiratory Diseases, Department of Promozione della Salute, Materno Infantile, Medicina Interna e Specialistica di Eccellenza "G. D'Alessandro" - PROMISE - University of Palermo; Palermo, Italy.ORCID 0000-0001-6400-6573
Salvatore BattagliaDivision of Respiratory Diseases, Dipartimento di Promozione della Salute, Materno Infantile, Medicina Interna e Specialistica di Eccellenza "G. D'Alessandro" (PROMISE), University of Palermo, Piazza delle Cliniche n. 2, Palermo 90127, Italy.ORCID 0000-0002-2867-917X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundBronchiectasis exacerbations are a significant contributor to morbidity and mortality. While environmental factors, such as viral infections, are well-established triggers for exacerbations, the role of intrinsic factors, particularly chronic bacterial infections, remains incompletely understood.

objectivesIn this context, we sought to investigate the impact of chronic bacterial infections using the COVID-19 pandemic as a natural experiment, providing a unique opportunity to assess the effects of reduced external infections.

designA retrospective observational cohort study was conducted involving patients with non-cystic fibrosis bronchiectasis.

methodsData were collected via telephone interviews and medical record reviews, comparing exacerbation rates before (2019) and during (2020) the pandemic. The difference in exacerbation rates between 2020 and 2019 (delta exacerbations) served as the dependent variable in a multiple regression model.

resultsSixty-three patients were included in the analysis. Those without chronic bacterial infections showed a significant reduction in exacerbations during the pandemic: mean (SD) was 1.06 (1.3) versus 1.61 (1.3), respectively (

conclusionWhile social distancing effectively reduced bronchiectasis exacerbations in patients without chronic bacterial infections, those with

Indexed as

Bacterial InfectionsBronchiectasisCOVID-19Pseudomonas InfectionsAgedDisease ProgressionFemaleHumansMaleMiddle AgedPseudomonas aeruginosaRetrospective StudiesRisk Factorsbronchiectasischronic infectioncommunicable disease controlexacerbationspseudomonas aeruginosa

Identifiers

PMID41174999
PMCPMC12580516

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.