Evidence map›Paper›PMID 41174898›Full record

ReviewCytoskeleton (Hoboken, N.J.)2026

Post-Translational Modifications of Tubulin in Oocyte Maturation and Female Infertility.

Changying Wang, Runhan Guo, Xuenan Wang, Hua Li, Tao Zhong

Abstract readReview
In one paragraph

Review in Cytoskeleton (Hoboken, N.J.), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Changying WangInstitute of Immunology and Molecular Medicine, Key Laboratory of Cell and Biomedical Technology of Shandong Province, College of Basic Medicine, Jining Medical University, Jining, China.
Runhan GuoInstitute of Immunology and Molecular Medicine, Key Laboratory of Cell and Biomedical Technology of Shandong Province, College of Basic Medicine, Jining Medical University, Jining, China.
Xuenan WangAffiliated Hospital of the Jining Medical University, Jining, China.
Hua LiDepartment of Gynecology and Obstetrics, Ji'nan Maternity and Child Care Hospital, Ji'nan, China.
Tao ZhongInstitute of Immunology and Molecular Medicine, Key Laboratory of Cell and Biomedical Technology of Shandong Province, College of Basic Medicine, Jining Medical University, Jining, China.ORCID https://orcid.org/0000-0003-3898-057X

Funding

High-Level Talents in the Medical and Health Industry in Ji'nan 202412Ji'nan Municipal Health Commission Science and Technology Plan Project 2023-1-43Key R&D Plan of Jining City 2023YXNS228National Natural Science Foundation of China 82101864Natural Science Foundation of Shandong Province ZR2025MS508Shandong Provincial Youth Innovation Technology Support Program 2023KJ262
6 · The paper itself

Abstract

Microtubules are critical components of the cytoskeleton that are extensively involved in various cellular and biological processes. The execution of these functions is intricately linked to post-translational modifications of tubulin. Post-translational modifications of tubulin include acetylation, tyrosination, de-tyrosination, glutamylation, SUMOylation, and so on. These modifications are closely associated with a wide range of biological processes. Accumulating evidence indicates that aberrant microtubule modifications are implicated in various diseases, including cancer, Alzheimer's disease, neurodevelopmental disorders, cardiac atrial hypertrophy, and even infertility. Aneuploid oocytes are a common cause of infertility, spontaneous abortion, trisomy syndrome, and other congenital abnormalities. The occurrence of aneuploidy is often closely associated with defects in spindle assembly, which are influenced by a series of tubulin modifications. In this review, we aimed to summarize the factors that affect tubulin modification and explore the key mechanisms underlying aneuploidy in human oocytes, thereby providing new insights and strategies for the treatment of infertility and prevention of congenital defects in newborns.

Indexed as

Infertility, FemaleOocytesProtein Processing, Post-TranslationalTubulinAnimalsFemaleHumansTubulinmicrotubuleoocytespost‐translational modification

Identifiers

PMID41174898
PMCPMC13485198

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.