Evidence map›Paper›PMID 41174811›Full record

Observational studyCritical care (London, England)2025

Indirect calorimetry identifies hypermetabolism associated with muscle wasting and increased risk of energy deficit in ICU patients.

Janusz von Renesse, Moritz Karl Friedrich von Kessel, Florian Oehme, Johanna Kirchberg, Mikheil Kalandarishvili, Heiner Nebelung, Felix Merboth, Peter Mirtschink, Jürgen Weitz, Marius Distler and 3 more

Abstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Critical care (London, England), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Janusz von RenesseDepartment of Visceral, Thoracic and Vascular Surgery, University Hospital and Faculty of Medicine Carl Gustav Carus, Technische Universität Dresden, 01307, Dresden, Germany. janusz.vonrenesse@ukdd.de.ORCID http://orcid.org/0000-0002-5103-5137
Moritz Karl Friedrich von KesselInstitute and Polyclinic for Diagnostic and Interventional Radiology, University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany.
Florian OehmeDepartment of Visceral, Thoracic and Vascular Surgery, University Hospital and Faculty of Medicine Carl Gustav Carus, Technische Universität Dresden, 01307, Dresden, Germany.
Johanna KirchbergDepartment of Visceral, Thoracic and Vascular Surgery, University Hospital and Faculty of Medicine Carl Gustav Carus, Technische Universität Dresden, 01307, Dresden, Germany.
Mikheil KalandarishviliDepartment of Visceral, Thoracic and Vascular Surgery, University Hospital and Faculty of Medicine Carl Gustav Carus, Technische Universität Dresden, 01307, Dresden, Germany.
Heiner NebelungInstitute and Polyclinic for Diagnostic and Interventional Radiology, University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany.
Felix MerbothDepartment of Visceral, Thoracic and Vascular Surgery, University Hospital and Faculty of Medicine Carl Gustav Carus, Technische Universität Dresden, 01307, Dresden, Germany.
Peter MirtschinkInstitute for Clinical Chemistry and Laboratory Medicine, University Hospital and Faculty of Medicine, Technische Universität Dresden, Dresden, Germany.
Jürgen WeitzDepartment of Visceral, Thoracic and Vascular Surgery, University Hospital and Faculty of Medicine Carl Gustav Carus, Technische Universität Dresden, 01307, Dresden, Germany.
Marius DistlerDepartment of Visceral, Thoracic and Vascular Surgery, University Hospital and Faculty of Medicine Carl Gustav Carus, Technische Universität Dresden, 01307, Dresden, Germany.
Hanns-Christoph HeldUniversity Centre of Surgery Intensive Care Unit, University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany.
Jens-Peter KühnInstitute and Polyclinic for Diagnostic and Interventional Radiology, University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany.
Ronny MeisterfeldDepartment of Visceral, Thoracic and Vascular Surgery, University Hospital and Faculty of Medicine Carl Gustav Carus, Technische Universität Dresden, 01307, Dresden, Germany. ronny.meisterfeld@ukdd.de.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND &

aimsMuscle mass loss is a major contributor to morbidity and mortality in Intensive Care Unit (ICU) patients, but the role of metabolic state - particularly energy expenditure - in this process remains unclear. This study investigates the association between metabolic status and muscle mass loss in critically ill adults using indirect calorimetry and CT imaging assessed muscle quantification.

methodsIn this observational study, adult ICU patients with at least two indirect calorimetry measurements and matched abdominal CT scans were included. Resting energy expenditure (REE) was measured by indirect calorimetry, and muscle mass was quantified as the cross-sectional area (CSA) of the posterior muscle group at the L3 vertebral level. Statistical analyses included regression modeling and group comparisons.

resultsThe observational study included 88 patients (n = 88), all of whom underwent at least two calorimetric measurements with corresponding CT scans, and 43 patients (n = 43) had at least three assessments. Persistently elevated normalized energy expenditure per kilogram of body weight (nREE) was independently associated with greater muscle loss. Patients classified as hypermetabolic by nREE experienced significantly more muscle wasting than those with lower metabolic activity. Hypermetabolism was associated with increased inflammatory markers, while sedation or agitation (RAAS) and higher level of consciousness (GCS) were not related to metabolic state.

conclusionsPersistent hypermetabolism in ICU patients is independently associated with accelerated muscle mass loss. Early identification of hypermetabolic patients using indirect calorimetry may enable targeted nutritional interventions to reduce muscle mass wasting and improve clinical outcomes.

Indexed as

Calorimetry, IndirectEnergy MetabolismMuscular AtrophyAdultAgedCritical IllnessFemaleHumansIntensive Care UnitsMaleMiddle AgedTomography, X-Ray ComputedCachexiaCritical illnessHypermetabolic patientsHypermetabolismHypermetabolizersIndirect calorimetryIntensive care unit (ICU)Muscle lossMuscle wastingResting energy expenditure (REE)Sarcopenia

Identifiers

PMID41174811
PMCPMC12579395

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.