ArticleDiabetology & metabolic syndrome2025
Relationship between hemoglobin glycation index and all-cause mortality in patients with acute myocardial infarction: based on MIMIC-IV database.
Article in Diabetology & metabolic syndrome, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- Hemoglobin Glycation Index and Prognosis in Patients With Acute Myocardial Infarction Without Reduced Left Ventricular Ejection Fraction: A Multicenter Retrospective Cohort Study.Journal of diabetes · 2026Article
- Association between hemoglobin glycation index and all-cause mortality in patients with non-ST-segment elevation myocardial infarction undergoing percutaneous coronary intervention.Frontiers in endocrinology · 2026Article
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4 authors.
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Abstract
backgroundThe Hemoglobin Glycation Index (HGI) assesses the discrepancy between actual and estimated Hemoglobin A1c (HbA1c) levels. Research exploring the connection between HGI and negative outcomes in patients with acute myocardial infarction (AMI) is notably lacking. The current study seeks to examine how HGI is related to the likelihood of death in people suffering from AMI.
methodsData on individuals suffering from AMI originated in the MIMIC-IV database. A proportional hazards regression model using the Cox method was applied to investigate the association between HGI and mortality. Furthermore, an investigation into the dose-response relationship between HGI and mortality was carried out using restricted cubic spline (RCS) analysis. To confirm the reliability of our results, subgroup analyses were conducted across different variables.
resultsThe research involved a group of 3,972 patients who were critically ill and had been diagnosed with AMI. A fully adjusted Cox regression analysis revealed a significant association between lower HGI levels and increased mortality rates at both 30-day and 365-day follow-ups. Furthermore, higher HGI levels were also linked to an increased risk of mortality within the first 30 days. An RCS analysis detected a U-shaped relationship connecting HGI to mortality rates at the 30-day and 365-day time intervals. Subgroup analyses and interaction tests further substantiated these findings, demonstrating that the association held true across various patient subgroups.
conclusionAmong critically ill AMI patients, a marked link emerged between HGI levels and all-cause mortality.
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