Evidence map›Paper›PMID 41174770›Full record

ArticleEye and vision (London, England)2025

Localising OCTA changes induced by the isometric hand-grip test to the superficial retina in neovascular age-related macular degeneration.

Matt Trinh, Yoh Ghen Tee, Judy Nam, Simon Chen, Gary Schiller, Jeff Friedrich, David Ng, Angelica Ly, Chris Hodge, Lisa Nivison-Smith

Abstract read
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In one paragraph

Article in Eye and vision (London, England), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

10 authors.

Matt TrinhSchool of Optometry and Vision Science, University of New South Wales, Sydney, NSW, 2015, Australia. m.trinh@unsw.edu.au.ORCID http://orcid.org/0000-0002-6184-0666
Yoh Ghen TeeSchool of Optometry and Vision Science, University of New South Wales, Sydney, NSW, 2015, Australia.
Judy NamSchool of Optometry and Vision Science, University of New South Wales, Sydney, NSW, 2015, Australia.
Simon ChenVision Eye Institute, Sydney, NSW, Australia.
Gary SchillerVision Eye Institute, Sydney, NSW, Australia.
Jeff FriedrichVision Eye Institute, Sydney, NSW, Australia.
David NgVision Eye Institute, Sydney, NSW, Australia.
Angelica LySchool of Optometry and Vision Science, University of New South Wales, Sydney, NSW, 2015, Australia.
Chris HodgeVision Eye Institute, Sydney, NSW, Australia.
Lisa Nivison-SmithSchool of Optometry and Vision Science, University of New South Wales, Sydney, NSW, 2015, Australia.

Funding

Future Vision Foundation 2023
6 · The paper itself

Abstract

purposeThis study uses optical coherence tomography angiography (OCTA) topographical cluster analysis to localise where vascular changes occur during the isometric hand-grip test (IHGT) in eyes with neovascular age-related macular degeneration (AMD).

methodsThis prospective study included single eyes from 44 participants with neovascular AMD. Systemic blood pressure (BP) and macular 6 × 6 mm OCTA scans were obtained before the IHGT, during the IHGT, and after the IHGT. The main outcome was the change in processed OCTA signal (%), measured within high-density (126 × 126) grids and analysed by topographical clusters across the superficial retina, deep retina, and choriocapillaris. Results were compared against test-retest thresholds to differentiate true IHGT-induced changes from measurement variability.

resultsThe IHGT increased systolic (13.83 [3.28, 24.39] mmHg) and diastolic BP (7.04 [3.57, 10.52] mmHg; P < 0.01). Adjusted for test-retest thresholds, the IHGT increased processed OCTA signal (12.84 [8.49, 26.77] %, P < 0.0001) at nasal clusters in the superficial retina. These changes were moderately correlated with systolic BP increases (Spearman r = 0.43, P < 0.05), but not with diastolic BP. No changes were observed in the deep retina or choriocapillaris. Systemic BP and processed OCTA signal returned to baseline within 30 s after IHGT release.

conclusionHand-squeezing temporarily increases processed OCTA signal in the nasal superficial retina. This response may serve as a valuable marker of vascular function. Consequently, caution is warranted when interpreting OCTA following BP changes, such as those induced by physical activity or medication changes.

Indexed as

Choroidal vascular flowIsometric exerciseNeovascular age-related macular degenerationOptical coherence tomography angiographyRetinal vascular flow

Identifiers

PMID41174770
PMCPMC12579405

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