Evidence map›Paper›PMID 41174752›Full record

ArticleTrials2025

Mini-simple limbal epithelial transplantation and conjunctival-limbal autograft for the treatment of primary pterygium: Study protocol for a randomized controlled trial.

Guillermo Raul Vera-Duarte, Gustavo Ortiz-Morales, Carlos Adolfo Müller-Morales, Alejandro Navas, Arturo Ramirez-Miranda, Enrique O Graue-Hernandez, Nicolás Kahuam-López

Registry-linked trialAbstract readClinical Trial Protocol
In one paragraph

Article in Trials, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06402643 (Comparative Analysis of Recurrence Rate Between Mini-Slet), which is not on this map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06402643 naunknown statusnot on this map

Comparative Analysis of Recurrence Rate Between Mini-Slet (Simple Limbal Epithelial Transplantation) Versus Limbal-Conjunctival Autograft Techniques in Primary Pterygium Excision

TypeinterventionalSponsorInstituto de Oftalmología Fundación Conde de ValencianaRan2024 to 2025Enrolled68ConditionsPterygium of Right Eye, Pterygium of Left Eye, Pterygium of Both Eyes, PterygiumArmsPterygium Excision
3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Guillermo Raul Vera-DuarteInstituto de Oftalmología Fundacion Conde de Valenciana IAP, Mexico City, Mexico.
Gustavo Ortiz-MoralesInstituto de Oftalmología Fundacion Conde de Valenciana IAP, Mexico City, Mexico.
Carlos Adolfo Müller-MoralesInstituto de Oftalmología Fundacion Conde de Valenciana IAP, Mexico City, Mexico.
Alejandro NavasInstituto de Oftalmología Fundacion Conde de Valenciana IAP, Mexico City, Mexico.
Arturo Ramirez-MirandaInstituto de Oftalmología Fundacion Conde de Valenciana IAP, Mexico City, Mexico.
Enrique O Graue-HernandezInstituto de Oftalmología Fundacion Conde de Valenciana IAP, Mexico City, Mexico.
Nicolás Kahuam-LópezInstituto de Oftalmología Fundacion Conde de Valenciana IAP, Mexico City, Mexico. nkahuam@gmail.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundPterygium is a wing-shaped fibrovascular growth over the cornea that may require surgical removal due to recurrence and cosmetic concerns. This randomized controlled trial compares the recurrence rate of conjunctival-limbal autograft (CLAu) with a modified mini-simple limbal epithelial transplant (mini-SLET) technique.

methods68 patients will be randomly assigned to two equally sized groups via simple randomization. Group I will undergo a pterygium excision with CLAu, while Group II will undergo a pterygium excision using a mini-SLET. Allocation concealment will be ensured using sealed envelopes, and procedures will be performed by two surgeons. Patients will be followed postoperatively at regular intervals for up to 12 months. DISCUSSION: This study builds on previous research by modifying the mini-SLET technique to enhance corneal stem cell viability and reduce recurrence. By refining this method, we aim to offer patients a more effective and minimally invasive alternative to the gold-standard procedure.

trial registrationClinicalTrials.gov, NCT06402643. Registered on April 15, 2024.

Indexed as

ConjunctivaCorneal TransplantationEpithelium, CornealLimbus CorneaePterygiumAdultAutograftsFemaleHumansMaleRandomized Controlled Trials as TopicRecurrenceTime FactorsTransplantation, AutologousTreatment OutcomeConjunctivo-limbal autograft (CLAu)Mini-simple limbal epithelial transplantation (Mini-SLET)Primary pterygiumRecurrence

Identifiers

PMID41174752
PMCPMC12576972

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.