ArticleBMC public health2025
Interaction between physical frailty and sleep quality on risk of migraine in later life: a cohort study of over 350,000 participants.
Article in BMC public health, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- Frailty and risk of common chronic diseases among cancer survivors: a prospective cohort study.Journal of cancer survivorship : research and practice · 2026Article
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5 authors.
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Abstract
backgroundFrailty was associated with neurological disorders, but has not been extrapolated to migraine. It's unclear whether maintaining healthy sleep mitigates this association. We examined the independent, joint, and interactive relationships between frailty status and sleep quality and migraine risk.
methods356,326 participants from the UK Biobank without migraine at baseline were included. The five-component Fried phenotype was used to assess frailty status and categorized participants as non-frail, pre-frail, and frail. A five-factor sleep questionnaire was employed to quantify sleep quality and categorize individuals into poor, intermediate, and healthy sleep. Cox proportional hazard models were applied to calculate the hazard ratios (HRs) and 95% confidence intervals (CIs). Their interactions on the multiplicative and additive scales were also assessed.
resultsDuring a median follow-up of 13.6 years, 4,641 (1.3%) participants experienced migraine. Compared with non-frail individuals, the HRs (95% CIs) for migraine were 1.149 (1.079-1.222) and 1.413 (1.225-1.630) for those with pre-frailty and frailty. Individuals with intermediate (HR = 1.170; 95% CI: 1.101-1.243) and poor (HR = 1.353; 95% CI: 1.146-1.598) sleep showed an increased risk of migraine compared to those with healthy sleep. The joint test suggested that frail individuals with poor sleep faced the highest migraine risk (HR = 1.897; 95% CI: 1.339-2.687), with evidence of an additive interaction. Also, healthy sleep weakened the frailty-migraine relationship, with evidence of a multiplicative interaction (P for interaction = 0.014).
conclusionAlthough both frailty and poor sleep quality are associated with a higher risk of migraine, achieving healthy sleep might mitigate the adverse impact of frailty.
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