ArticleNutrition journal2025
Investigating the role of homocysteine and B vitamins in gestational diabetes mellitus: Mendelian randomization study.
Article in Nutrition journal, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- Elevated homocysteine levels are associated with increased diabetes risk in patients with hypertension: a multicenter longitudinal study.Frontiers in cardiovascular medicine · 2026Article
- Folic Acid Therapy is Associated with a Lower Risk of Incident Diabetes and Better Glycemic Status in Patients with Coronary Heart Disease: Findings from a Multicenter Propensity Score-Matched Analysis.Drug design, development and therapy · 2026Article
- The roles of folate, MTHFR genetics, vitamin B12 in pregnancy outcomes.Frontiers in nutrition · 2026Review
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundGestational diabetes mellitus (GDM) is a significant pregnancy complication, and its relationship with serum levels of B vitamins and homocysteine (Hcy) remains unclear. This study aims to investigate the causal associations between genetically predicted serum levels of B vitamins (vitamin B6, B12, and folate) and Hcy with GDM risk.
methodsIndependent single nucleotide polymorphisms (SNPs) associated with Hcy (n = 14), Hcy (independent of BMI) (n = 11), vitamin B6 (n = 16), vitamin B12 (n = 8), folate (n = 14), and folate (independent of BMI) (n = 13) were selected as instrumental variables (IVs) based on genome-wide significance. Summary-level data for GDM were sourced from the FinnGen consortium.
resultsThe MR analysis demonstrated a significant association between serum Hcy levels and GDM risk [OR (95% CI) = 1.28 (1.09, 1.51), p = 0.003] using the inverse variance weighting (IVW) method. Following the exclusion of BMI-related IVs, a suggestive association was observed between serum Hcy levels and GDM risk [OR (95% CI) = 1.26 (1.04, 1.54), p = 0.019].
conclusionsOur study indicates a suggestive association between Hcy levels and GDM, emphasizing the necessity for additional research to explore the role of Hcy in GDM management.
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