ArticleBMC oral health2025
Layer by layer nanocoating of chlorhexidine-loaded micelles on polymethyl methacrylate denture base.
Article in BMC oral health, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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4 authors.
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Abstract
backgroundDenture stomatitis is a prevalent oral infection commonly affecting denture wearers with inadequate oral hygiene cares. This susceptibility stems from the porous and rough nature of denture bases, which readily harbor bacteria and promote plaque accumulation. This study aimed to modify the surface of denture bases with a chlorhexidine (CHX) coating to promote antimicrobial activity against Candida albicans.
methodsDenture bases were coated with chlorhexidine-loaded poly(ethylene glycol)-block-poly(ε-caprolactone) micelles (CHX-micelles) using the solvent evaporation method. The surface was coated using a layer-by-layer (LbL) dip coating process involving CHX-micelles and poly(acrylic acid) (PAA). The total number of LbL coating cycles was adjusted, and the coating thickness, drug content, CHX-release, antimicrobial activity, and toxicity of the coated denture base were evaluated. One-way ANOVA and Two-way ANOVA were performed. Statistical significance is defined as p < 0.05.
resultsThe optimized coated denture base, with 90 layers, achieved a maximum coating thickness of 13.33 ± 2.41 μm and a CHX content of 23.64 ± 4.71 µg/cm
conclusionThe development of antimicrobial denture bases using this coating method has shown promising results. The optimized coating effectively prolonged CHX release, inhibited fungal growth, and maintained biocompatibility.
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