Evidence map›Paper›PMID 41174574›Full record

ArticleBMC biology2025

A putative auxin efflux carrier FgAec1 contributes to the pathogenicity of Fusarium graminearum.

Su Hu, Haibin Zhao, Qin Wu, Qiantao Jiang, Jian Ma, Pengfei Qi, Guoyue Chen, Youliang Zheng, Yuming Wei, Qiang Xu

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Su Hu *State Key Laboratory of Crop Gene Exploration and Utilization in Southwest China, Sichuan Agricultural University, Chengdu, Sichuan, China.
Haibin Zhao *Engineering Research Center of Microbial Resources Development and Green Recycling of Shaanxi Province, Yan'an University, Yan'an, 716000, China.
Qin WuState Key Laboratory of Crop Gene Exploration and Utilization in Southwest China, Sichuan Agricultural University, Chengdu, Sichuan, China.
Qiantao JiangState Key Laboratory of Crop Gene Exploration and Utilization in Southwest China, Sichuan Agricultural University, Chengdu, Sichuan, China.
Jian MaState Key Laboratory of Crop Gene Exploration and Utilization in Southwest China, Sichuan Agricultural University, Chengdu, Sichuan, China.
Pengfei QiState Key Laboratory of Crop Gene Exploration and Utilization in Southwest China, Sichuan Agricultural University, Chengdu, Sichuan, China.
Guoyue ChenState Key Laboratory of Crop Gene Exploration and Utilization in Southwest China, Sichuan Agricultural University, Chengdu, Sichuan, China.
Youliang ZhengState Key Laboratory of Crop Gene Exploration and Utilization in Southwest China, Sichuan Agricultural University, Chengdu, Sichuan, China.
Yuming WeiState Key Laboratory of Crop Gene Exploration and Utilization in Southwest China, Sichuan Agricultural University, Chengdu, Sichuan, China. ymwei@sicau.edu.cn.
Qiang XuState Key Laboratory of Crop Gene Exploration and Utilization in Southwest China, Sichuan Agricultural University, Chengdu, Sichuan, China. xuqiang1264700418@163.com.

Funding

Doctoral research initiation project of Yan'an University YAU202507839National Natural Science Foundation of China 32102229the Biotech Breeding Program of State Key Laboratory of Crop Gene Exploration and Utilization in Southwest China SKL-ZY202233the Sichuan Science and Program 2024NSFSC0405
6 · The paper itself

Abstract

backgroundAuxin is crucial for plant growth and influences plant-pathogen interactions. Pathogen-produced indole-3-acetic acid (IAA) is crucial for pathogenicity; however, the role of plant-derived or pathogen-derived IAA in regulating plant defense responses remains poorly understood.

resultsIn this study, two putative auxin efflux carrier (AEC) proteins, FgAec1 and FgAec2, were identified in Fusarium graminearum. To study the effects of the pathogen-derived auxins on Fusarium head blight (FHB), knockout mutants of FgAec1 or FgAec2 showed no effect on vegetative growth or conidia morphology. However, the Δfgaec1 mutant (but not the Δfgaec2 mutant) exhibited reduced growth and development in wheat spikes, indicating that FgAec1 is a key pathogenic factor. Deletion of FgAec1 reduced auxin efflux during the wheat-F. graminearum interaction, whereas exogenous auxin restored the pathogenicity of Δfgaec1 in wheat spikes. Knockout of FgAec1 enhanced the salicylic acid (SA)-mediated defense signaling pathway in response to F. graminearum. Additionally, deletion of a nitrilase FgNIT2 gene, involved in IAA synthesis in F. graminearum, reduced fungal pathogenicity and affected the expression of the SA-responsive genes in wheat treated with F. graminearum. The SA-deficient taics-AB mutant plant inoculated with Δfgaec1 demonstrated that a reduction in the auxin pool may increase the plant's resistance to the Δfgaec1 strain by disrupting the balance of auxin-SA crosstalk.

conclusionsThese results indicate that FgAec1 may act as a putative AEC, regulating auxin transport in F. graminearum and mediating F. graminearum-wheat interactions. These findings provide new insights into the role of auxin biosynthesis in F. graminearum in suppressing host plant defenses.

Indexed as

Fungal ProteinsFusariumIndoleacetic AcidsPlant DiseasesTriticumVirulenceFungal ProteinsIndoleacetic AcidsAuxin efflux carrierFusarium graminearumPlant defensesSalicylic acidWheat

Identifiers

PMID41174574
PMCPMC12577076

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.