ArticleCancer cell international2025
miR-196a-5p promotes the proliferation, migration, and invasion of esophageal squamous cell carcinoma by targeting LIFR.
Article in Cancer cell international, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundEsophageal squamous cell carcinoma (ESCC) is a prevalent and aggressive malignancy. While microRNAs (miRNAs) are known to play a critical regulatory role in the occurrence and progression of ESCC, the underlying mechanisms remain incompletely understood. Therefore, the aim of this study was to investigate the effect of miR-196a-5p on the proliferation, migration, and invasion of ESCC and its mechanism.
methodsThe role of miR-196a-5p in the progression of ESCC was explored with CCK8, colony formation, and Transwell assays, and Western blot analysis was used to detect epithelial-mesenchymal transition (EMT). The regulatory effect of miR-196a-5p on ESCC was further verified through a xenograft experiment on nude mice.
resultsmiR-196a-5p was significantly upregulated in ESCC, and the overexpression of miR-196a-5p considerably promoted the proliferation, migration, and invasion of ESCC cells in vitro. The expression level of E-cadherin decreased, while N-cadherin and vimentin increased, indicating that the EMT of ESCC cells was promoted. Conversely, miR-196a-5p downregulation had the opposite effects. In vivo experiments confirmed that miR-196a-5p overexpression promoted ESCC proliferation and EMT. Furthermore, we identified leukemia inhibitory factor receptor (LIFR) as a target gene of miR-196a-5p in ESCC and was negatively regulated by miR-196a-5p. LIFR overexpression can rescue the ability of miR-196a-5p to promote ESCC cell proliferation and invasion, and offset the cell migration and EMT caused by miR-196a-5p.
conclusionsmiR-196a-5p promotes the proliferation, migration, and invasion of ESCC by targeting LIFR and regulating the EMT, highlighting its potential as a diagnostic biomarker and therapeutic target.
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