ArticleBMC infectious diseases2025
Evaluation of vancomycin utilization in medical and pediatric wards: a retrospective cross-sectional study at Bule Hora University Teaching Hospital, Ethiopia.
Article in BMC infectious diseases, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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1 citing paper in PubMed.
- Inappropriate antibiotic utilization in hospitalized patients in Ethiopia: A systematic review and meta-analysis.Exploratory research in clinical and social pharmacy · 2026Review
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4 authors.
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Abstract
backgroundVancomycin is a critical antibiotic used for serious Gram‑positive infections, particularly methicillin‑resistant Staphylococcus aureus (MRSA). However, inappropriate use contributes to antimicrobial resistance (AMR). Limited evidence exists on the extent and appropriateness of vancomycin utilization in Ethiopian hospitals.
objectivesTo evaluate the prescribing pattern and appropriateness of vancomycin use in medical and pediatric wards at Bule Hora University Teaching Hospital (BHUTH).
methodsA retrospective cross‑sectional study was conducted among 182 patient medical records reviewed. Data were extracted using a structured checklist adapted from the Ethiopian Standard Treatment Guidelines (STG). Patient sociodemographic characteristics, clinical profiles, vancomycin prescribing pattern, appropriateness, and outcomes were assessed. Data were analyzed using the Statistical Package for the Social Sciences version 27. Descriptive statistics were employed and results presented in tables and figures.
resultsOf 182 patients admitted, 81 (44.8%) received vancomycin, mainly for pyogenic meningitis (78.9%) and severe community‑acquired pneumonia (13.3%). Prescribing appropriateness was 84.6% for indication, 96.3% for dose, and 98.7% for frequency, but lower for duration (71.6%). All prescriptions were empirical, with no microbiological confirmation. Ceftriaxone was the most frequent co‑prescribed drug (42.0%). Among vancomycin recipients, 74.1% improved, 11.1% died, and no adverse drug reactions were documented.
conclusionVancomycin utilization at BHUTH demonstrated generally appropriate indication, dosing and frequency, but all prescriptions were empirical, without microbiological confirmation, and nearly one‑third had inappropriate treatment duration. These practices increase the risk of antimicrobial resistance, especially given vancomycin's WHO AWaRe classification as a Watch antibiotic.
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