Observational studyBMC infectious diseases2025
Comparison of fully-vaccinated and non/partially-vaccinated critically-ill COVID-19 patients in terms of disease severity: a retrospective observational study.
Observational study in BMC infectious diseases, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04430322 (Coronavirus Disease 2019), which is not on this map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Coronavirus Disease 2019 (Covid-19) at the Regional Hospital Center Metz-Thionville: a Descriptive Study
Who cites it
2 citing papers in PubMed.
- Acute Respiratory Failure and Ventilatory Support in Hospitalized Adults With Viral Respiratory Infection: A Retrospective Cohort Study.Open forum infectious diseases · 2026Article
- COVID-19 vaccination remains essential for healthcare professionals: clinical evidence from a Polish cross-sectional study.Frontiers in public health · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundCritical care admissions due to breakthrough COVID-19 in fully vaccinated patients remain rare. There is limited data on their characteristics and outcomes compared to non- or partially vaccinated patients, and no studies have evaluated the impact of variants of concern.
methodThis study used the COMETE-19 (COVID-19 patients in the intensive care unit [ICU]) near real-time prospective registry, a tool launched on March 1, 2020, to track patient and disease characteristics as well as the disease course of critically ill COVID-19 patients in two French ICUs. Fully vaccinated patients were compared with non- or partially vaccinated patients. The primary outcome was a composite criterion of severity, including invasive mechanical ventilation (IMV), other organ assistance, or death. Differences between the vaccinated and control groups regarding other outcomes, patient variables, management, and SARS-CoV-2 variants were explored using univariate analysis. Factors associated with high disease severity in both groups were examined using logistic regression analysis.
resultsA total of 805 patients (median age, 65 years [IQR 56-71], 67% male) were enrolled. Of these, 41 (5%) were fully vaccinated. Fully vaccinated patients required less frequent IMV (27% vs. 51%, p = 0.003) and had lower mortality (15% vs. 26%, p = 0.026). Full vaccination status was associated with lower disease severity (OR 0.30; CI95% [0.11-0.74]; p = 0.011) and tended to prevent ICU mortality (OR 0.39, CI95% [0.13-1.04], p = 0.072). Variants-of-concern did not associate with outcomes.
conclusionAmong critically ill COVID-19 patients, full vaccination was associated with less severe disease progression compared to partial or no vaccination.
trial registrationClinical Trial: NCT04430322.
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Registered trials
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