ArticleBMC gastroenterology2025
Low pillow height is associated with LPR among patients with GERD: a retrospective single-center study.
Article in BMC gastroenterology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
Abstract
objectiveGastroesophageal reflux disease (GERD) combined with laryngo-pharyngeal reflux (LPR) has poor drug efficacy, which seriously affects their mental health and quality of life. Investigation of the risk factors and construct predictive models to improve preventive strategies.
methodsA total of 323 GERD patients (192 with simple GERD, 131 with LPR) and 225 healthy controls were enrolled in Yijishan Hospital of Wannan Medical College. All participants underwent sedated upper endoscopy with laryngeal examination. They were evaluated using the GerdQ, RSI, and RFS instruments, and relevant risk factors were analyzed via questionnaire.
resultsSedated upper endoscopy demonstrated value in detecting laryngeal reflux. Significant differences existed between healthy controls and GERD patients for age, waist circumference, high-fat diet, eating too fast, overeating, supine after meals, anxiety, and depression (all p ≤ 0.05). GERD + LPR patients differed significantly from GERD-only patients in high-fat diet, eating too fast, overeating, supine position after meals (≤ 30 min), low pillow height, cervical spondylosis, and anxiety (p ≤ 0.05). Multivariable analysis identified six independent correlates ranked by effect size: low pillow height (largest) > supine position after meals > anxiety > eating too fast > overeating > high-fat diet. The 6-factor nomogram model achieved an Area Under Curve (AUC) of 0.775 (95% CI: 0.723 ~ 0.826), with bootstrap-validated AUC of 0.772 (95% CI: 0.768 ~ 0.776). Calibration was satisfactory, and Decision Curve (DCA) indicated clinical utility across a wide probability range.
conclusionLow pillow height was the strongest correlate of GERD + LPR in this cohort, and sedated upper endoscopy can effectively observe laryngopharyngeal inflammation and assist the diagnosis of LPR. This model provides an internally validated exploratory tool for clinical identification of high-risk patients, aiding early identification and personalized prevention.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.