ArticleBMC infectious diseases2025
A qualitative burden of disease study in patients with invasive Escherichia coli disease aged ≥ 60 years in the United States.
Article in BMC infectious diseases, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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1 citing paper in PubMed.
- From the gut to the lungs: The role of gut microbiota in chronic obstructive pulmonary disease and related research progress.Microbial cell (Graz, Austria) · 2026Article
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13 authors.
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Abstract
backgroundInvasive Escherichia coli disease (IED) comprises a diverse range of severe infections caused by E. coli, mainly affecting neonates and older adults, and is associated with severe and sometimes fatal outcomes. This study aimed to evaluate signs and symptoms associated with IED, and to assess the impact of IED on health-related quality of life (HRQoL) among older patients. Furthermore, we examined how generic patient-reported outcomes questionnaires capture experiences of patients with IED.
methodsA cross-sectional qualitative study consisting of semi-structured interviews was conducted. Participants aged ≥ 60 years who met the IED clinical case definition were enrolled within 2 weeks after the disease episode and asked to describe IED signs and symptoms and HRQoL impact through open-ended questions. The interview transcripts were analyzed using NVivo 12 and a conceptual model was built. The concepts for impacts identified by participants with IED were then compared with the concepts routinely assessed by two generic HRQoL instruments: the 36-Item Short Form Survey (SF-36) and EuroQol 5-Dimension (EQ-5D).
resultsOf 80 patients screened, 43 met inclusion criteria and 16 consented to participate in the study. The interviews showed that IED affected daily routines and activities (n = 13), ability to move and sleep (both n = 11), and caused exhaustion (n = 10) as well as constant pain (n = 9). Most HRQoL impacts identified were also measured in SF-36 and EQ-5D, but concepts specific for patients with IED, not measured in SF-36 and EQ-5D, were also recognized.
conclusionsIED was shown to cause substantial physical, social, and psychological impacts in patients. This burden was especially apparent in review of patient self-reports for concepts that are part of generic HRQoL instruments (SF-36, EQ-5D), and patients also frequently reported neurological/mental impacts. Further, this study provides valuable qualitative data that may be useful for future research in developing a disease-specific instrument for the assessment of HRQoL in patients with IED.
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