Article in Nature nanotechnology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registry
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what money
Authors and funding
15 authors.
Yixin Zhong *Center of Interventional Radiology and Vascular Surgery, Department of Radiology, Zhongda Hospital & Basic Medicine Research and Innovation Center of Ministry of Education, Southeast University, Nanjing, China.ORCID http://orcid.org/0009-0007-0753-8144
Qiankun Ni *CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, CAS Center for Excellence in Nanoscience, National Center for Nanoscience and Technology of China, Beijing, China.ORCID http://orcid.org/0000-0002-4969-183X
Liandi Huang *Chongqing Key Laboratory of Ultrasound Molecular Imaging & Department of Radiology, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, China.ORCID http://orcid.org/0009-0008-7859-6373
Guangchao Qing *CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, CAS Center for Excellence in Nanoscience, National Center for Nanoscience and Technology of China, Beijing, China.ORCID http://orcid.org/0000-0002-7278-5869
Fuxue ZhangCAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, CAS Center for Excellence in Nanoscience, National Center for Nanoscience and Technology of China, Beijing, China.ORCID http://orcid.org/0000-0003-1708-8873
Ningqiang GongDepartment of General Surgery, The First Affiliated Hospital of USTC, Division of Life Science and Medicine, University of Science and Technology of China, Hefei, China.ORCID http://orcid.org/0000-0002-9444-8505
Hongyun WuChongqing Key Laboratory of Ultrasound Molecular Imaging & Department of Radiology, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, China.
Yukun LiaoChongqing Key Laboratory of Ultrasound Molecular Imaging & Department of Radiology, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, China.
Huiting JiangChongqing Key Laboratory of Ultrasound Molecular Imaging & Department of Radiology, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, China.ORCID http://orcid.org/0000-0002-0756-834X
Zaiqian TuCAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, CAS Center for Excellence in Nanoscience, National Center for Nanoscience and Technology of China, Beijing, China.
Zhifei WangCAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, CAS Center for Excellence in Nanoscience, National Center for Nanoscience and Technology of China, Beijing, China.ORCID http://orcid.org/0009-0004-4265-3795
Luksika JiramonaiCAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, CAS Center for Excellence in Nanoscience, National Center for Nanoscience and Technology of China, Beijing, China.ORCID http://orcid.org/0009-0009-9976-138X
Haidong ZhuCenter of Interventional Radiology and Vascular Surgery, Department of Radiology, Zhongda Hospital & Basic Medicine Research and Innovation Center of Ministry of Education, Southeast University, Nanjing, China.
Gao-Jun TengCenter of Interventional Radiology and Vascular Surgery, Department of Radiology, Zhongda Hospital & Basic Medicine Research and Innovation Center of Ministry of Education, Southeast University, Nanjing, China. gjteng@seu.edu.cn.ORCID http://orcid.org/0000-0003-1145-0798
Xing-Jie LiangCAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, CAS Center for Excellence in Nanoscience, National Center for Nanoscience and Technology of China, Beijing, China. liangxj@nanoctr.cn.ORCID http://orcid.org/0000-0002-4793-1705
Funding
National Natural Science Foundation of China (National Science Foundation of China) 32030060National Natural Science Foundation of China (National Science Foundation of China) 82130060National Natural Science Foundation of China (National Science Foundation of China) 82302364
6 · The paper itself
Abstract
Antiplatelet drugs have represented a milestone in treating patients at high risk of thrombosis. However, their clinical use remains limited by bleeding-associated risk and limited efficacy. Excessive reactive oxygen species (ROS) produced by damaged vascular endothelial cells have been shown to stimulate thrombosis. Here we propose that a ROS-chemotactic nanoscavenger (MDCP), formed by crosslinking melanin and catalase, prevents acute thrombosis by protecting vascular endothelial cells from oxidative stress. We demonstrate that treatment with MDCP inhibits ROS-induced apoptosis of endothelial cells, thereby maintaining endothelial integrity and preventing collagen exposure, which consequently prevents platelet activation and thrombosis. By avoiding direct interference with platelet function, this modulation of vascular redox homeostasis via MDCP provides a promising alternative antithrombotic strategy that addresses the bleeding risk of current clinical antithrombotic drugs.
Indexed as
AntioxidantsEndothelium, VascularThrombosisAnimalsApoptosisCatalaseEndothelial CellsHumansOxidative StressPlatelet ActivationReactive Oxygen SpeciesAntioxidantsCatalaseReactive Oxygen Species
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.
Prevention of acute thrombosis with vascular endothelium antioxidative nanoscavenger. · full record | OpenQuestion